Physical fitness and executive decision-making in people at risk for Alzheimer's
Official title: Physical Fitness and Hot Executive Function in Alzheimer's Risk
Run by National Taiwan Normal University · NCT07081269 · Data updated 2026-11-12
Over 18 months, this project will see if changes in cardiorespiratory and muscle fitness predict changes in executive thinking and EEG brain signals in adults aged 50–70 who are at risk for Alzheimer's.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 50 Years to 70 Years |
| Sex | All |
| Enrollment | 240 (estimated) |
| Sponsor | National Taiwan Normal University Academic / other |
| Locations | 1 site (Taipei) |
| Status | Recruiting |
| Started | January 10, 2025 |
| Main results expected | July 31, 2027 |
| Study ends | July 31, 2027 |
| Registry record updated | July 23, 2025 |
| Trial ID | NCT07081269 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 50–70 who can safely complete submaximal and strength fitness testing, have normal or corrected vision, and do not have major cardiopulmonary, neurological, psychiatric, or infectious illnesses.
✕Probably not a fit
People with dementia or other major neurological/psychiatric disorders, cardiopulmonary disease, active infections, medications that affect brain function, or color-vision deficiency are excluded and would not be expected to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study follows adults aged 50–70 for 18 months to examine links between health-related physical fitness and both behavioral and electrophysiological measures of executive function. Participants complete baseline and 18-month visits that include YMCA submaximal cycle ergometry for cardiorespiratory fitness, one-repetition maximum chest and leg press for muscular strength, and computerized task-switching paradigms with simultaneous EEG recording. Secondary measures include the MMSE, digit span, physical activity questionnaires, demographics, and APOE ε4 genotyping to explore moderation effects. No exercise program is provided, so the study captures natural changes in fitness and cognition in daily life.
Why it matters
Potential benefit: If successful, the findings could identify fitness markers that predict cognitive decline and help guide early lifestyle strategies to preserve thinking skills.
How similar studies have gone: Previous observational work has linked higher cardiorespiratory fitness to better executive function and EEG markers, though causal evidence is limited and this study builds on those associations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 50-70. * Able to engage in fitness testing. * Normal vision or corrected-to-normal vision. Exclusion Criteria: * Suffering from cardiopulmonary-related diseases. * Suffering from cognitive, neurological or psychiatric disorders (e.g., dementia, Parkinson's disease, epilepsy, depression, schizophrenia, etc.). * Suffering from infectious diseases (e.g., hepatitis, human immunodeficiency virus or Creutzfeldt-Jakob disease). * Having a history of drug or alcohol abuse. * Having colour vision deficiency (e.g., colour blindness). * Having a family history of aneurysm. * Taking medications that affect brain function.
Where it's running
-
National Taiwan Normal University
Taipei, Taiwan Recruiting
Study contacts
- Principal investigator: Chine-Heng Chu, PhD — National Taiwan Normal University
- Study coordinator: Chine-Heng Chu, PhD
- Email: cchu042@yahoo.com
- Phone: +886277493224
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.