Physical exercise and cognitive training to improve quality of life in older adults
Official title: Health-related Quality of Life in Elderly Adults Following Physical Exercise and Cognitive Training: a Randomized-controlled Trial
Run by University Hospital of Ferrara · NCT07244536 · Data updated 2026-11-12
This project will test whether physical exercise, cognitive training, or both can improve quality of life, thinking, and mobility in people aged 70 and older.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 70 Years and up |
| Sex | All |
| Enrollment | 156 (estimated) |
| Sponsor | University Hospital of Ferrara Academic / other |
| Locations | 1 site (Ferrara) |
| Status | Recruiting |
| Started | November 15, 2025 |
| Main results expected | October 31, 2027 |
| Study ends | October 31, 2028 |
| Registry record updated | December 12, 2025 |
| Trial ID | NCT07244536 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal participants are people aged 70 or older who can give informed consent, are able to partake in physical exercise, and do not have severe cognitive impairment or major visual loss.
✕Probably not a fit
Patients with absolute contraindications to exercise, severe cognitive impairment (MoCA ≤ 12), severe visual impairment, or who cannot attend in-person sessions are unlikely to benefit from this program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial enrolls adults aged 70 and older and assigns them to one of three intervention groups combining physical exercise and/or cognitive training. Interventions are delivered in person at a single center and are intended to target quality of life, cognitive performance, and mobility. Outcome measures will include standardized quality-of-life questionnaires, cognitive tests such as the MoCA, and mobility assessments over the intervention period. Participants with absolute contraindications to exercise, severe cognitive impairment, or severe visual loss are excluded.
Why it matters
Potential benefit: If effective, the interventions could help older adults preserve or improve quality of life, thinking skills, and physical mobility.
How similar studies have gone: Previous trials have shown modest benefits of physical exercise and cognitive training on mobility and cognition in older adults, though results for combined interventions have been mixed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male and female * Age ≥ 70 years * Provision of the informed consent form Exclusion Criteria: * Absolute contraindications to physical exercise (e.g. NYHA class IV heart failure, unstable angina, etc.) * Pregnancy * Severe cognitive impairment, defined as a MoCa score ≤ 12 * Severe visual impairment or blindness
Where it's running
-
Esercizio Vita
Ferrara, Italy Recruiting
Study contacts
- Study coordinator: Luca Pomidori Principal Investigator, PhD
- Email: luca.pomidori@gmail.com
- Phone: 00393455984607
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.