Physical activity and brain health in former athletes and sedentary adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a cross-sectional observational comparison of former competitive athletes who still exercise regularly and adults who are sedentary. The study uses a multiscale approach, combining neuropsychological testing, neuroimaging, peripheral blood biomarkers, and genetic analyses to characterize brain health. Participants must have maintained their activity or sedentary pattern for at least six months and have no history of major neurological, psychiatric, or serious medical conditions. All testing is performed at the Faculty of Physical Activity and Sports Sciences (INEF) in Madrid.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Group A: ex-athletes and continue to perform regular physical exercise (minimum 3 days/week of moderate-vigorous intensity).
* Group B: sedentary individuals, (i.e., perform \<150 min of moderate intensity exercise per week or IPAQ score\<600 MET min/week).
* In both groups (A and B) the conditions of physical exercise or sedentary lifestyle must have been maintained for at least 6 months prior to the evaluations.
* Not having a history of neurological or psychiatric disorder or suffering from a serious medical condition

Exclusion Criteria:

* Medical conditions that have a high risk of associated cognitive symptoms.
* Severe head injury with loss of consciousness within the previous 5 years.
* Alcoholism (\>3 alcoholic drinks per day).
* Chronic use of anxiolytics, neuroleptics, narcotics, anticonvulsants, or sedative hypnotics.
* Hearing or visual impairment that would preclude testing
* History of neurological disease with clinically relevant impact on cognition (e.g. cerebrovascular disease).
* Incidental structural brain findings with impact on cognitive impairment or survival (e.g., malignant brain tumor).
* Presence of severe systemic disease (e.g., cancer under treatment).
* Consumption of anabolic substances.
* Problems understanding spoken or written Spanish.
* Those with pacemakers or metallic implants that may interfere with the MRI.

Where it's running

• Faculty of Physical Activity and Sports Sciences (INEF)
  Madrid, Madrid, Spain Recruiting

Study contacts

• Study coordinator: Songxin Tang
• Email: songxin.tang@alumnos.upm.es
• Phone: +34 663002621

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.