Photobiomodulation (low-level laser) for knee bleeds in children with hemophilia
Effects of Photobiomodulation on Knee Hemarthosis in Patients With Hemophilia.
This project tests whether photobiomodulation (low-level laser) added to standard care can reduce pain and swelling and improve knee movement in children with hemophilia aged 9–14 who have knee hemarthrosis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 9 Years to 14 Years |
| Sex | All |
| Sponsor | Riphah International University Academic / other |
| Locations | 1 site (Sialkot, Punjab Province) |
| Trial ID | NCT07579585 on ClinicalTrials.gov |
What this trial studies
This quasi-experimental study at Sundas Foundation (Sialkot, Pakistan) will enroll 24 children with hemophilia and knee hemarthrosis using convenience sampling. Participants will receive low-level laser therapy (photobiomodulation) for 10 minutes, three times per week, in addition to their usual clotting factor replacement and physiotherapy after an acute internal knee bleed. Primary outcomes include pain intensity measured by the Visual Analogue Scale, knee swelling measured objectively, and joint range of motion; outcomes will be compared before and after the intervention. The protocol was approved by BASAR and follows standard clinical safety exclusions for wounds, joint subluxation, major skeletal deformities, cardiopulmonary dysfunction, and neurological deficits.
Who should consider this trial
Good fit: Ideal candidates are children aged 9–14 years with hemophilia who currently have knee hemarthrosis and do not have open wounds, knee subluxation, major skeletal deformities, cardiopulmonary dysfunction, or neurological deficits.
Not a fit: Patients with open wounds near the treatment site, knee joint subluxation, congenital or acquired skeletal deformities, cardiopulmonary dysfunction, neurological deficits, or those outside the 9–14 age range are unlikely to be eligible or benefit from this protocol.
Why it matters
Potential benefit: If successful, the therapy could offer a safe, non-invasive adjunct that reduces pain and swelling and improves knee mobility in children with hemophilia.
How similar studies have performed: Low-level laser therapy has shown promise for reducing inflammation and musculoskeletal pain in other conditions, but its specific benefit for hemarthrosis in hemophilia is largely untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Hemophilia patients with knee hemarthosis * Patients of age 9-14 yrs will be taken * Bothmaleand female population will be included Exclusion Criteria: * Presence of open wounds at or near the treatment site. * Kneejoint subluxation. * Presence of congenital or acquired skeletal deformities. * Children diagnosed with cardiopulmonary dysfunctions. * Children with neurological deficits
Where this trial is running
Sialkot, Punjab Province
- Sundas Foundation — Sialkot, Punjab Province, Pakistan (Recruiting)
Study contacts
- Principal investigator: Zaira Zeeshan, MS — Riphah International University
- Study coordinator: Imran Amjad, PhD
- Email: imran.amjad@riphah.edu.pk
- Phone: 03324390125
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.