Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 20 to 40 Women only

Phenylephrine 75 micrograms versus 50 micrograms to prevent oxytocin-related low blood pressure during cesarean

Official title: Effects of Two Different Doses of Phenylephrine co Administration on Oxytocin- Induced Hemodynamic Effects

Run by Rawalpindi Medical College · NCT07420127 · Data updated 2026-11-12

This trial will test whether a 75 µg or 50 µg bolus of phenylephrine given with oxytocin better prevents drops in blood pressure in women having elective cesarean sections under spinal anesthesia.

Quick facts

PhasePhase 4
Study typeInterventional
Ages20 Years to 40 Years
SexWomen only
Enrollment112 (estimated)
SponsorRawalpindi Medical College
Academic / other
Locations1 site (Rawalpindi, Punjab Province)
StatusRecruiting
StartedFebruary 13, 2026
Main results expectedJuly 13, 2026
Study endsJuly 13, 2026
Registry record updatedFebruary 24, 2026
Trial IDNCT07420127 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Women with a singleton pregnancy scheduled for elective cesarean section under spinal anesthesia who do not have placental abnormalities, hypertensive disorders, or concurrent beta-blocker or vasodilator therapy.

Probably not a fit

Patients undergoing emergency cesarean, those with multiple pregnancies, placental abnormalities, hypertensive disorders, or taking beta-blockers/vasodilators are unlikely to benefit from the results or be eligible to participate.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

After delivery during an elective cesarean under spinal anesthesia, participants will receive oxytocin as usual and be given either a 75 µg or 50 µg bolus of phenylephrine to prevent hypotension. Blood pressure will be closely monitored and any need for additional vasopressors or adverse events will be recorded. The trial excludes women with placental abnormalities, hypertensive disorders, or those taking beta-blockers or vasodilators. The primary comparison is the incidence and severity of oxytocin-induced hypotension between the two dose groups.

Why it matters

Potential benefit: If successful, the trial could identify a prophylactic dose that reduces maternal low blood pressure and the need for rescue medications during cesarean delivery.

How similar studies have gone: Previous clinical work has shown phenylephrine effectively prevents oxytocin-related hypotension, but the optimal single bolus prophylactic dose remains unsettled.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

\- Females having a singleton pregnancy Patients planned for elective cesarean section under spinal anesthesia

Exclusion Criteria:

* Patients having a placental abnormality

  * Patients taking beta-blocker and vasodilator therapy
  * Patients with hypertensive disorder

Where it's running

  • Department of Anesthesia, Holy Family Hospital, Rawalpindi
    Rawalpindi, Punjab Province, Pakistan
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.