Phenylephrine 75 micrograms versus 50 micrograms to prevent oxytocin-related low blood pressure during cesarean
Effects of Two Different Doses of Phenylephrine co Administration on Oxytocin- Induced Hemodynamic Effects
This trial will test whether a 75 µg or 50 µg bolus of phenylephrine given with oxytocin better prevents drops in blood pressure in women having elective cesarean sections under spinal anesthesia.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 112 (estimated) |
| Ages | 20 Years to 40 Years |
| Sex | Female |
| Sponsor | Rawalpindi Medical College Academic / other |
| Locations | 1 site (Rawalpindi, Punjab Province) |
| Trial ID | NCT07420127 on ClinicalTrials.gov |
What this trial studies
After delivery during an elective cesarean under spinal anesthesia, participants will receive oxytocin as usual and be given either a 75 µg or 50 µg bolus of phenylephrine to prevent hypotension. Blood pressure will be closely monitored and any need for additional vasopressors or adverse events will be recorded. The trial excludes women with placental abnormalities, hypertensive disorders, or those taking beta-blockers or vasodilators. The primary comparison is the incidence and severity of oxytocin-induced hypotension between the two dose groups.
Who should consider this trial
Good fit: Women with a singleton pregnancy scheduled for elective cesarean section under spinal anesthesia who do not have placental abnormalities, hypertensive disorders, or concurrent beta-blocker or vasodilator therapy.
Not a fit: Patients undergoing emergency cesarean, those with multiple pregnancies, placental abnormalities, hypertensive disorders, or taking beta-blockers/vasodilators are unlikely to benefit from the results or be eligible to participate.
Why it matters
Potential benefit: If successful, the trial could identify a prophylactic dose that reduces maternal low blood pressure and the need for rescue medications during cesarean delivery.
How similar studies have performed: Previous clinical work has shown phenylephrine effectively prevents oxytocin-related hypotension, but the optimal single bolus prophylactic dose remains unsettled.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Females having a singleton pregnancy Patients planned for elective cesarean section under spinal anesthesia Exclusion Criteria: * Patients having a placental abnormality * Patients taking beta-blocker and vasodilator therapy * Patients with hypertensive disorder
Where this trial is running
Rawalpindi, Punjab Province
- Department of Anesthesia, Holy Family Hospital, Rawalpindi — Rawalpindi, Punjab Province, Pakistan (Recruiting)
Study contacts
- Study coordinator: Farwa Javed Principal Investigator, MBBS
- Email: farwajaved44@gmail.com
- Phone: +92 304 8954091
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.