Phenylephrine 75 micrograms versus 50 micrograms to prevent oxytocin-related low blood pressure during cesarean
Official title: Effects of Two Different Doses of Phenylephrine co Administration on Oxytocin- Induced Hemodynamic Effects
Run by Rawalpindi Medical College · NCT07420127 · Data updated 2026-11-12
This trial will test whether a 75 µg or 50 µg bolus of phenylephrine given with oxytocin better prevents drops in blood pressure in women having elective cesarean sections under spinal anesthesia.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 20 Years to 40 Years |
| Sex | Women only |
| Enrollment | 112 (estimated) |
| Sponsor | Rawalpindi Medical College Academic / other |
| Locations | 1 site (Rawalpindi, Punjab Province) |
| Status | Recruiting |
| Started | February 13, 2026 |
| Main results expected | July 13, 2026 |
| Study ends | July 13, 2026 |
| Registry record updated | February 24, 2026 |
| Trial ID | NCT07420127 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women with a singleton pregnancy scheduled for elective cesarean section under spinal anesthesia who do not have placental abnormalities, hypertensive disorders, or concurrent beta-blocker or vasodilator therapy.
✕Probably not a fit
Patients undergoing emergency cesarean, those with multiple pregnancies, placental abnormalities, hypertensive disorders, or taking beta-blockers/vasodilators are unlikely to benefit from the results or be eligible to participate.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
After delivery during an elective cesarean under spinal anesthesia, participants will receive oxytocin as usual and be given either a 75 µg or 50 µg bolus of phenylephrine to prevent hypotension. Blood pressure will be closely monitored and any need for additional vasopressors or adverse events will be recorded. The trial excludes women with placental abnormalities, hypertensive disorders, or those taking beta-blockers or vasodilators. The primary comparison is the incidence and severity of oxytocin-induced hypotension between the two dose groups.
Why it matters
Potential benefit: If successful, the trial could identify a prophylactic dose that reduces maternal low blood pressure and the need for rescue medications during cesarean delivery.
How similar studies have gone: Previous clinical work has shown phenylephrine effectively prevents oxytocin-related hypotension, but the optimal single bolus prophylactic dose remains unsettled.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Females having a singleton pregnancy Patients planned for elective cesarean section under spinal anesthesia Exclusion Criteria: * Patients having a placental abnormality * Patients taking beta-blocker and vasodilator therapy * Patients with hypertensive disorder
Where it's running
-
Department of Anesthesia, Holy Family Hospital, Rawalpindi
Rawalpindi, Punjab Province, Pakistan Recruiting
Study contacts
- Study coordinator: Farwa Javed Principal Investigator, MBBS
- Email: farwajaved44@gmail.com
- Phone: +92 304 8954091
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.