Pharmacogenetic testing for mothers and children
Official title: Knowledge and Attitudes Regarding Pharmacogenetic Testing Among Children With Chronic Conditions and Pregnant Women
Run by Vanderbilt University Medical Center · NCT05037305 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if providing educational videos about genetic testing for medications at different times helps pregnant women and children understand and use this information better.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Vanderbilt University Medical Center Academic / other |
| Locations | 2 sites (Nashville, Tennessee and 1 other locations) |
| Trial ID | NCT05037305 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include pregnant women aged 18 and older who are receiving care at Vanderbilt University Medical Center and children aged 0 to 16 whose parents consent to participate.
✕Probably not a fit
Patients who have undergone prior pharmacogenomic testing or those with recent organ transplants may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to enhance the understanding and implementation of pharmacogenetic testing for children and pregnant women. It will involve collecting DNA samples and demographic information from participants, followed by a survey assessing knowledge and attitudes towards pharmacogenetics. Participants will be randomized into two groups, one receiving an educational video about pharmacogenetic testing at the time of results, and the other receiving it later. The study seeks to address gaps in pharmacogenetic data, particularly for underrepresented populations.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective medication management for mothers and children based on their genetic profiles.
How similar studies have gone: While pharmacogenetic testing has been explored in various populations, this specific focus on pregnant women and children is relatively novel and under-researched.
Who can join: the full rules
Show full inclusion / exclusion criteria
Maternal Inclusion Criteria: * Provide consent in English or Spanish * Primary care at VUMC * Adult women aged 18 and older * Currently pregnant 12 to 30 weeks gestational age * Completed or scheduled first prenatal visit at VUMC clinic * Intent to deliver at VUMC or affiliate * Agrees to receive findings from pharmacogenomic testing * Allow access their medical record Exclusion Criteria: * Stem cell or solid organ transplant * Recent transfusion within the previous 2 months * Inability to provide DNA sample for testing * Prior pharmacogenomic testing * Pregnant women undergoing in vitro fertilization or assisted reproductive technologies Pediatric Inclusion Criteria: * Provide consent (parent/guardian) and/or assent (child) in English or Spanish * Primary care or subspecialty care at VUMC * Aged 0 to 16 * Parent (0-16 years) and child (12-16 years) agree for both parent and child to receive findings from pharmacogenomic testing * Parent (0-16 years) and child (12-16 years) allow access their medical record * Have a chronic health condition. Exclusion: * Stem cell or solid organ transplant * Recent transfusion within the previous 2 months * Inability to provide DNA sample for testing * Prior pharmacogenomic testing
Where it's running
-
Monroe Carell Jr. Children's Hospital at Vanderbilt
Nashville, Tennessee, United States Recruiting -
Vanderbilt University Medical Center
Nashville, Tennessee, United States Recruiting
Study contacts
- Study coordinator: Sabrina E Holley, MD
- Email: sabrina.e.holley@vumc.org
- Phone: 6158754491
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Preventing medication-related side effects and falls in older adults after an ER visit
This project will test whether giving doctors patients' DNA results to guide prescribing can reduce medication side effects and falls in adults 65 and older who come to the emergency department after a ground-level fall.
-
Parasite and Infestation Experience: Understanding What People Feel and Think
This observational study tests how people who strongly believe they have parasites or infestation feel and think, even when doctors say otherwise.
-
Corticosteroid for Diabetic Macular Edema (DME) in Adults with Diabetic Retinopathy
This trial tests whether intravitreal corticosteroid injections can influence inflammatory biomarkers and improve DME in adults with type 2 diabetes.
-
Non-invasive test to predict early heart rejection in pediatric transplant patients
This study tests non-invasive heart tests like cardiac MRI and blood markers to see if they can detect rejection in kids after heart transplant, potentially reducing the need for invasive biopsies.
-
AR-guided resection planning for head and neck tumors
Aims to see if augmented reality guidance can help surgeons perform more precise re-sections in head and neck tumor cases using cadaver specimens.
-
Modeling heart failure in Duchenne and Becker muscular dystrophy to find surrogate heart measures
This study will look at heart disease in people with Duchenne/Becker muscular dystrophy and carriers to see if MRI-based heart measures can predict death or major heart problems.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.