Clinical trial Recruiting at 1 site Interventional Ages 18 to 100

Pharmacist-led Medication Therapy Management to improve anticoagulant safety after colorectal cancer surgery

Official title: The Impact of MTM Model on the Efficacy and Safety of Anticoagulant Therapy in Postoperative Colorectal Cancer Patients

Run by Sixth Affiliated Hospital, Sun Yat-sen University · NCT06998745 · Data updated 2026-11-12

This will try a pharmacist-led Medication Therapy Management (MTM) program to reduce blood clots and bleeding in people who had colorectal cancer surgery and are taking anticoagulants.

More Cerebral Venous Thrombosis trials

Quick facts

Study typeInterventional
Ages18 Years to 100 Years
SexAll
Enrollment327 (estimated)
SponsorSixth Affiliated Hospital, Sun Yat-sen University
Academic / other
Locations1 site (Guangzhou, Guangdong)
StatusRecruiting
StartedMay 1, 2025
Main results expectedDecember 30, 2027
Study endsDecember 30, 2027
Registry record updatedMay 31, 2025
Trial IDNCT06998745 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are postoperative colorectal cancer patients with symptomatic or incidental VTE who are currently receiving active anticoagulant therapy and have been treated for at least three months.

Probably not a fit

Patients who are not on active anticoagulant therapy, who have already completed anticoagulation, or who cannot attend hospital-based follow-up are unlikely to benefit from this program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional program integrates multifaceted pharmacist interventions at admission, during hospitalization, and after discharge to manage anticoagulant therapy in postoperative colorectal cancer patients with venous thromboembolism. The MTM model includes medication reconciliation, monitoring, individualized dosing and follow-up counseling to reduce inappropriate prescribing, premature treatment discontinuation, and adverse events. Participants are patients with histologically confirmed colorectal cancer who developed symptomatic or incidental VTE and are on active anticoagulant therapy for at least three months. The study compares outcomes of MTM-managed care against usual care to measure recurrent VTE, bleeding events, and overall medication appropriateness.

Why it matters

Potential benefit: If successful, the MTM program could lower recurrent clots and bleeding events and improve the appropriateness and continuity of anticoagulant treatment for postoperative colorectal cancer patients.

How similar studies have gone: Pharmacist-led anticoagulation management has improved prescribing appropriateness and reduced bleeding in other settings, but applying a comprehensive MTM model specifically to postoperative colorectal cancer patients is relatively novel and not yet conclusively proven.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Patients with histologically confirmed CRC and symptomatic or incidental VTE who received anticoagulant treatment.
2. CRC patients with VTE treated with an anticoagulant for at least 3 moths.

Exclusion Criteria:

1.Participation in this study required active anticoagulant treatment. Apart from this, there were no specific exclusion criteria.

Where it's running

  • Sixth Affiliated Hospital, Sun Yat-sen University
    Guangzhou, Guangdong, China
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.