Pharmacist-led Medication Therapy Management to improve anticoagulant safety after colorectal cancer surgery
Official title: The Impact of MTM Model on the Efficacy and Safety of Anticoagulant Therapy in Postoperative Colorectal Cancer Patients
Run by Sixth Affiliated Hospital, Sun Yat-sen University · NCT06998745 · Data updated 2026-11-12
This will try a pharmacist-led Medication Therapy Management (MTM) program to reduce blood clots and bleeding in people who had colorectal cancer surgery and are taking anticoagulants.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 327 (estimated) |
| Sponsor | Sixth Affiliated Hospital, Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | May 1, 2025 |
| Main results expected | December 30, 2027 |
| Study ends | December 30, 2027 |
| Registry record updated | May 31, 2025 |
| Trial ID | NCT06998745 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are postoperative colorectal cancer patients with symptomatic or incidental VTE who are currently receiving active anticoagulant therapy and have been treated for at least three months.
✕Probably not a fit
Patients who are not on active anticoagulant therapy, who have already completed anticoagulation, or who cannot attend hospital-based follow-up are unlikely to benefit from this program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional program integrates multifaceted pharmacist interventions at admission, during hospitalization, and after discharge to manage anticoagulant therapy in postoperative colorectal cancer patients with venous thromboembolism. The MTM model includes medication reconciliation, monitoring, individualized dosing and follow-up counseling to reduce inappropriate prescribing, premature treatment discontinuation, and adverse events. Participants are patients with histologically confirmed colorectal cancer who developed symptomatic or incidental VTE and are on active anticoagulant therapy for at least three months. The study compares outcomes of MTM-managed care against usual care to measure recurrent VTE, bleeding events, and overall medication appropriateness.
Why it matters
Potential benefit: If successful, the MTM program could lower recurrent clots and bleeding events and improve the appropriateness and continuity of anticoagulant treatment for postoperative colorectal cancer patients.
How similar studies have gone: Pharmacist-led anticoagulation management has improved prescribing appropriateness and reduced bleeding in other settings, but applying a comprehensive MTM model specifically to postoperative colorectal cancer patients is relatively novel and not yet conclusively proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients with histologically confirmed CRC and symptomatic or incidental VTE who received anticoagulant treatment. 2. CRC patients with VTE treated with an anticoagulant for at least 3 moths. Exclusion Criteria: 1.Participation in this study required active anticoagulant treatment. Apart from this, there were no specific exclusion criteria.
Where it's running
-
Sixth Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Principal investigator: xiaoyan li — Sixth Affiliated Hospital, Sun Yat-sen University
- Study coordinator: xiaoyan li
- Email: lixyan5@mail.sysu.edu.cn
- Phone: 13609066172
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Evaluating mechanical thrombectomy for deep vein thrombosis
This study is testing if a procedure called mechanical thrombectomy can safely help people with serious blood clots in their legs feel better.
-
Bioimpedance and light-based monitoring during abdominal flap weaning in breast reconstruction
This study tests a portable bioimpedance device alongside light and temperature measurements to monitor a breast reconstruction flap during arterial and venous weaning in adult women.
-
Danang Cerebral Venous Thrombosis Registry
This registry collects information on adults with cerebral venous thrombosis admitted to Danang Hospital to see how the condition presents, what imaging shows, risk factors, and how patients recover.
-
Anticoagulation Plus Tocilizumab for Acute Cerebral Venous Thrombosis
This study tests whether adding a single dose of tocilizumab to standard blood thinners helps people with acute cerebral venous thrombosis.
-
Anticoagulation plus batroxobin for acute cerebral venous thrombosis
This trial tests whether adding batroxobin to standard anticoagulation helps adults with acute cerebral venous thrombosis.
-
DOAC treatment outcomes for cerebral venous thrombosis in Vietnam
This project will try direct oral anticoagulants (dabigatran or rivaroxaban) in adults with cerebral venous thrombosis to see if they are safe and effective in routine care.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.