Phacoemulsification with goniosynechialysis versus trabeculectomy for primary angle-closure glaucoma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, parallel-group, single-masked trial will assign adults with primary angle-closure glaucoma to either phacoemulsification with goniosynechialysis (Phaco-GSL) or trabeculectomy with 5‑fluorouracil. Allocation is stratified by age and disease severity, and all procedures are performed by experienced glaucoma surgeons following standardized surgical and postoperative protocols. Key outcomes include intraocular pressure at predefined intervals, IOP reduction from baseline, rates of postoperative complications, visual acuity recovery, and need for glaucoma medications. Participants attend scheduled visits (e.g., 1 week, 1 month, 3 months, 6 months, 12 months) for standardized eye exams and pressure checks to compare groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 40 years
* Peripheral anterior synechiae (PAS) \>180°
* Glaucomatous optic neuropathy with visual field loss
* Intraocular pressure (IOP) \> 21 mmHg despite medication
* Ability to consent and comply with follow-up
* Cataract grade 1 to 3 according to LOCS III
* Best corrected visual acuity (BCVA) ≥ 0.3 logMAR (equivalent to 20/40 Snellen or worse)

Exclusion Criteria:

* Very advanced glaucoma (only light perception vision)
* Secondary angle-closure etiologies
* Prior ocular surgeries or laser peripheral iridotomy (PI)
* Allergy to 5-fluorouracil (5-FU), if used postoperatively
* Irreversible corneal disease
* Chronic corticosteroid use
* Poor follow-up compliance
* Cataract grade 4 or 5 (LOCS III)
* Phacomorphic, phacolytic, or subluxated cataracts

Where it's running

• HCMC University of Medicine and Pharmacy
  Ho Chi Minh City, Vietnam Recruiting

Study contacts

• Study coordinator: Hai Thanh Le, MSc
• Email: haileopto@gmail.com
• Phone: +61 450390405

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.