Personalized ventilatory strategy for patients with focal ARDS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates a ventilatory strategy tailored to the lung morphology of patients diagnosed with focal Acute Respiratory Distress Syndrome (ARDS). It aims to improve patient outcomes by adjusting mechanical ventilation based on ultrasound assessments of lung structure, as opposed to standard care. The study will include patients who have been on mechanical ventilation for less than 24 hours and have a recent diagnosis of focal ARDS. The approach is based on previous findings that suggest personalized ventilation may enhance survival rates compared to traditional methods.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* person who has given oral consent or has been included in an emergency
* Older than 18 years
* On mechanical ventilation for less than 24 hours
* Diagnosis of ARDS for less than 24 hours. ARDS according to the Berlin classification: i.e. arterial oxygen pressure to inspired oxygen fraction ratio less than or equal to 300, with a PEEP greater than or equal to 5, presence of bilateral radiological infiltrates not fully explained by heart failure or volume overload
* Focal ARDS determined on pulmonary ultrasound

Exclusion Criteria:

* person who is not a beneficiary of national health insurance
* person who is subject to a legal measure of protection (curatorship, guardianship)
* pregnant or breastfeeding women
* minor
* Patient having benefited from an invasive mechanical ventilation of more than one week in the previous month;
* ARDS in the previous month;
* Chronic respiratory failure under NIV or long term oxygen;
* Severe acute asthma;
* Lobectomy;
* Pneumothorax;
* Pneumomediastinum;
* Pulmonary fibrosis;
* Morbid obesity with a BMI above 40 ;
* Cancer with metastasis;
* Bone marrow transplantation;
* Chemotherapy-induced neutropenia;
* Cirrhosis with a Child-Pugh score of C;
* Suspected or confirmed intracranial hypertension;
* Concurrent participation in another ARDS study;
* Extensive burns on the torso.

Where it's running

• Chu Dijon Bourgogne
  Dijon, France Recruiting

Study contacts

• Study coordinator: BOUHEMAD Belaid
• Email: belaid.bouhemad@chu-dijon.fr
• Phone: 03 80 29 30 79

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.