Personalized treatment for urogenital cancers based on microbiome analysis
Official title: Personalized Treatment of Urogenital Cancers Depends on the Microbiome
Run by Zealand University Hospital · NCT03962920 · Data updated 2026-11-12
This study tests if giving antibiotics based on a person's microbiome can help improve recovery and treatment outcomes for people with localized urogenital cancers compared to those who get a placebo.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 70 Years |
| Sex | All |
| Enrollment | 28 (estimated) |
| Sponsor | Zealand University Hospital Academic / other |
| Locations | 1 site (Roskilde) |
| Status | Recruiting |
| Started | May 1, 2020 |
| Main results expected | May 1, 2025 |
| Study ends | May 1, 2027 |
| Registry record updated | January 30, 2024 |
| Trial ID | NCT03962920 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients with a biopsy-verified diagnosis of localized urological cancer.
✕Probably not a fit
Patients with a history of genitourinary tract cancers, recent hospitalization, or those with diabetes may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the impact of microbiome on the treatment of urogenital cancers by comparing two groups of patients undergoing surgical treatment. One group will receive antibiotics while the other will receive a placebo, allowing researchers to assess the role of microbiome in recovery and treatment outcomes. The study aims to determine if personalized treatment based on microbiome can improve patient outcomes in localized urological cancers.
Why it matters
Potential benefit: If successful, this approach could lead to more effective and personalized treatment strategies for patients with urogenital cancers.
How similar studies have gone: While the role of microbiome in cancer treatment is an emerging field, this specific approach has not been widely tested, making it a novel investigation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Biopsy verified diagnosis of urological cancer, localized disease Exclusion Criteria: * Hospitalization within three months of surgery * Antibiotics within three months of surgery * Infectious disease, including UTI's within three months of surgery * History of cancers of the genitourinary tract * Diabetes
Where it's running
-
Zealand University Hospital
Roskilde, Denmark Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Single-use gastroscopes vs reusable in elective and subacute gastroscopy
This study tests whether single-use gastroscopes work as well as reusable ones for adults having gastroscopy when endoscope reprocessing capacity is limited.
-
How dexamethasone affects blood sugar during and after non-cardiac surgery
We will see if a standard dose of dexamethasone raises blood sugar in adults having elective non-cardiac surgery and whether continuous glucose monitors detect changes better than finger-prick tests.
-
Calcium electroporation for bladder tumors in adults who can’t have standard treatments
This first‑in‑human study tests intravesical calcium electroporation to see if it is safe and whether it shows early signs of benefit in adults with bladder tumors who have few other options.
-
Connecting hospitalized patients to alcohol care
This pilot tests whether inviting in-hospital patients with alcohol use issues to meet an alcohol-use therapist for up to 10 sessions, versus giving guidance to seek care in the community, is feasible.
-
Singing training versus usual care after lung cancer surgery (6–18 months post-operation)
This trial will test whether an online singing program can help people who had surgery for early-stage non-small cell lung cancer 6–18 months ago feel better, breathe easier, and improve physical fitness.
-
Contrast-enhanced ultrasound to target liver metastases from colorectal cancer
This trial will try low- and high-intensity contrast-enhanced ultrasound in adults whose colorectal cancer has spread to the liver to see if it safely makes tumors more immune-active.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.