Personalized treatment for persistent vertigo caused by BPPV

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on patients suffering from refractory benign paroxysmal positional vertigo (BPPV), a common cause of vertigo that does not respond to standard treatments. It employs a personalized medicine approach using computational fluid dynamics (CFD) based on MRI scans to tailor canalith repositioning maneuvers (CRMs) to individual anatomical variations in the inner ear. Participants will be randomly assigned to receive either standard CRMs or personalized CRMs designed from their unique inner ear anatomy. The study aims to improve treatment outcomes for patients who have not found relief from conventional methods.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* A. Diagnosed with BPPVp according to the Barany Society criteria:

  1. Recurrent episodes of vertigo or positional instability, triggered by lying down or turning the head in the supine position.
  2. Episodes lasting less than 1 minute.
  3. Positional nystagmus observed after a latency period during the Dix-Hallpike test (DHT), with an upward vertical component and a torsional component (clockwise on the left side and counterclockwise on the right).
  4. Symptoms not explained by any other cause.

     AND
* B. Refractory to otolith repositioning maneuvers (Epley and/or Semont maneuvers), with persistence of symptoms after three attempts.

Exclusion Criteria:

* Cognitive impairment that prevents understanding of their condition and the required procedures.
* Pathological conditions that hinder the execution of the maneuvers.
* BPPV involving canals other than the posterior canal or bilateral posterior canal involvement.
* Low educational level, which may impede understanding of the procedures and informed consent.

Where it's running

• Hospital Clínico Universitario
  Santiago de Compostela, A Coruña, Spain Recruiting

Study contacts

• Principal investigator: Andrés Soto-Varela, Prof, PhD — Complexo Hospitalario Universitario de Santiago
• Study coordinator: Andrés Soto-Varela, Prof, PhD
• Email: andres.soto.varela@sergas.es
• Phone: +34981951157

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Personalized IV fluid care for sepsis in the emergency department

  This study will test whether giving IV fluids based on each adult's heart response helps people with suspected sepsis in the emergency department recover more safely than standard fluid care.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT07009665

• Comparing Wii Fit Training and Vestibular Rehabilitation for Balance in Vertigo Patients

  This study is testing whether using Wii Fit training or traditional vestibular rehab helps people with vertigo improve their balance better.

  Recruiting Foundation University Islamabad · Islamabad · NCT06738823

• Digital support system for treating childhood obesity

  This study tests if a new digital support system called Evira can help kids aged 4 to 17 manage their weight better when combined with regular lifestyle treatment.

  Recruiting at 2 sites Karolinska Institutet · Messina and 4 other locations · NCT04917601

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.