Personalized treatment for endometrial cancer using biomarkers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of using identified molecular biomarkers to tailor treatment for patients with endometrial cancer. It consists of two parts: the first focuses on optimizing surgical treatment through lymphadenectomy guided by validated biomarkers, while the second assesses the predictive potential of the biomarker stathmin for response to taxane treatment in endometrial and ovarian cancer. The goal is to enhance treatment individualization based on biomarker profiles.

Why it matters

Who can join: the full rules

Inclusion Criteria part 1:

All patients referred to a participating research centre with suspicion of or confirmed endometrial cancer.

Exclusion Criteria part 1:

1. Patients who do not have endometrial cancer
2. Patients who will or cannot give informed consent (including language barriers)
3. Patients \<18 years of age
4. Patients who will not get surgical treatment for their endometrial cancer

Inclusion criteria part 2:

1. Patients with endometrial or epithelial ovarian cancer who following routine clinical guidelines are offered weekly taxane (paclitaxel) treatment. This will often be a third or fourth line treatment, i.e. patients with advanced disease.
2. Technical possibility to obtain a new tissue biopsy to determine stathmin level in the tumour recurrence.

Exclusion criteria part 2:

1. Patients not suffering from endometrial or epithelial ovarian cancer
2. Patients \<18 years of age
3. Patients who do not agree to the proposed treatment or will receive (part of) the treatment in a non-participating centre
4. Patients who cannot or do not want to give informed consent (including language barriers)

Where it's running

• Women's hospital, Haukeland university hospital
  Bergen, Hordaland, Norway Recruiting
• Ålesund hospital
  Ålesund, Norway Recruiting
• Førde central hospital
  Førde, Norway Recruiting
• Akershus University hospital
  Oslo, Norway Recruiting
• Stavanger university hospital
  Stavanger, Norway Recruiting
• St Olav university hospital
  Trondheim, Norway Recruiting

Study contacts

• Principal investigator: Henrica MJ Werner, MD PhD MRCOG — Haukeland University Hospital
• Study coordinator: Jone Trovik, MD PhD Prof
• Email: jone.trovik@k2.uib.no
• Phone: +4755974200

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.