Personalized strength training for adults with hypokalemic or hyperkalemic periodic paralysis
Official title: Effect of Physical Training in Individuals With Hypokalemic and Hyperkalemic Periodic Paralysis
Run by Copenhagen University Hospital, Rigshospitalet · NCT07194174 · Data updated 2026-11-12
This study will try a 12-week personalized, supervised strength-training program for adults with genetically confirmed hypokalemic or hyperkalemic periodic paralysis to see if muscle strength and structure improve.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 36 (estimated) |
| Sponsor | Copenhagen University Hospital, Rigshospitalet Academic / other |
| Locations | 1 site (Copenhagen) |
| Status | Recruiting |
| Started | October 2, 2025 |
| Main results expected | December 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | March 30, 2026 |
| Trial ID | NCT07194174 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) with genetically confirmed hypokalemic or hyperkalemic periodic paralysis who can walk at least 10 meters independently and can rise from a chair without using their hands.
✕Probably not a fit
Patients with other significant causes of muscle weakness, unstable heart or lung disease that make exercise unsafe, or those unable to complete supervised training are unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a 24-week prospective study with clinical testing and questionnaires at baseline, 12 weeks, and 24 weeks. Between weeks 12 and 24 participants follow a personalized strength-exercise program supervised by study investigators. The protocol includes assessments of muscle structure and function, along with patient-reported outcomes. Eligible participants are adults with genetically confirmed HypoPP or HyperPP who can ambulate independently and stand from a chair without using their hands.
Why it matters
Potential benefit: If successful, the program could increase muscle strength and functional mobility and potentially reduce the frequency or severity of paralysis episodes.
How similar studies have gone: Small case series and exercise programs for neuromuscular channelopathies suggest safety and possible benefit, but there is limited high-quality evidence specifically in periodic paralysis.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with genetic verified HypoPP or HyperPP * Age minimum 18 years * Able to walk a minimum of 10 meters independently with or without assistive devices and be able to stand from a chair without using hands Exclusion Criteria: * Other significant cause of muscle weakness * Heart or lung disease which, in the investigator's opinion, makes participation in the study training inadvisable Exclusion from muscle biopsy * Anticoagulant treatment * Impaired blood clotting due to disease Exclusion from MRI scanning due to: * Metal implants in the body that contraindicate MRI scanning or are positioned such that the scan quality is significantly affected * Claustrophobia * Pregnancy
Where it's running
-
Rigshospitalet, Copenhagen Neuromuscular Center
Copenhagen, Denmark Recruiting
Study contacts
- Study coordinator: Annica B Enegaard
- Email: annica.buss.enegaard.01@regionh.dk
- Phone: +4535456135
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.