Personalized strength, balance and treadmill perturbation program to reduce falls in people with multiple myeloma
Investigation of Fall Risk Factors and Implementation of an Exercise Intervention for Prevention of Falls in Patients With Multiple Myeloma
NA · University Hospital Heidelberg · NCT07044427
This program tests whether a tailored combination of strength, balance, and treadmill perturbation exercises can reduce fall risk in adults receiving treatment for multiple myeloma.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital Heidelberg (other) |
| Locations | 1 site (Heidelberg, Baden Würtemberg) |
| Trial ID | NCT07044427 on ClinicalTrials.gov |
What this trial studies
Participants will receive a baseline fall-risk assessment to identify contributors such as muscle weakness, balance deficits, or other risk factors. Enrolled patients will follow a patient-specific exercise program combining supervised strength and balance training with treadmill-based perturbation sessions, performed at least three times weekly. The protocol includes regular follow-up visits to track changes in fall-risk measures, functional performance, and incidence of falls. The study aims to map fall risk factors in multiple myeloma patients and see if a structured exercise intervention lowers falls and related injuries.
Who should consider this trial
Good fit: Adults (≥18) with multiple myeloma receiving systemic therapy for at least six months, ECOG status ≤3, able and willing to perform the training program at least three times per week, attend follow-up visits, provide informed consent, and read/speak sufficient German.
Not a fit: Patients with physical or cognitive limitations that prevent safe participation in the exercise sessions or those unwilling/unable to attend regular training and follow-ups are unlikely to benefit.
Why it matters
Potential benefit: If successful, the program could reduce falls and fall-related injuries, helping patients maintain mobility and independence.
How similar studies have performed: Strength and balance training—and emerging perturbation training—have reduced falls in older adults, but these approaches have been little tested specifically in multiple myeloma patients.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with multiple myeloma requiring therapy (at least 6 months of systemic therapy) * ECOG status ≤ 3 * Age ≥18 years * Patients who state that they want to carry out the training program at least 3 times/week and participate in the planned follow-up visits * Ability to give informed consent * Written consent to participate in the study * Sufficient written and spoken German to complete the questionnaire Exclusion Criteria: * Any physical or mental limitations that would prevent participation in the training program or the planned follow-up checks.
Where this trial is running
Heidelberg, Baden Würtemberg
- University Hospital Heidelberg — Heidelberg, Baden Würtemberg, Germany (RECRUITING)
Study contacts
- Study coordinator: Ulrike Dapunt, prof. Dr. med
- Email: ulrike.dapunt@med.uni-heidelberg.de
- Phone: +49 622156 32765
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Multiple Myeloma, Fall Risk Factors, Strength Training Effects, Balance Training Effects, Fall risk, pertubation training, strength training, Balance