Personalized rTMS treatment for patients with persistent auditory hallucinations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on patients with refractory auditory hallucinations, particularly those diagnosed with schizophrenia. It employs magnetoencephalography (MEG) to identify individualized brain targets for repetitive transcranial magnetic stimulation (rTMS) treatment. The intervention consists of a structured regimen of rTMS sessions aimed at reducing the severity of auditory hallucinations, with careful monitoring and evaluation of patient responses throughout the process. The study aims to explore the effectiveness of personalized treatment plans based on precise brain localization.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical diagnosis of schizophrenia
* Must be able to right-handed
* Primary school education or above
* Understand and sign a written informed consent form (jointly signed by the guardian and the participant if under 18 years old)
* Existence of persistent auditory hallucinations (defined as: taking sufficient antipsychotic medication for at least 6 months, combined with 3 antipsychotic medications still ineffective, and no significant improvement in auditory hallucinations symptoms, with an AHRS score still\>12)

Exclusion Criteria:

* MECT treatment within the past 3 months
* Major physical illnesses (organic lesions such as sensory and motor disorders, neurological disorders, and traumatic brain injury)
* Taboo symptoms for rTMS treatment (such as intracranial metal implants)
* Aggressive behavior and an impulse to damage equipment
* Metal (including orthodontic treatment, dental implants) and tattoos inside the body
* Claustrophobia

Where it's running

• Shanghai Mental Health Center
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Yegang Hu, Doctor
• Email: yeganghu@126.com
• Phone: +86-21-52219305

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.