Personalized rTMS treatment for individuals at high risk of psychosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of repetitive transcranial magnetic stimulation (rTMS) tailored to individual brain targets identified through magnetoencephalography (MEG) in patients diagnosed with Clinical High-Risk Syndrome for Psychosis. The approach involves first determining the precise locations of abnormal brain signals using MEG, followed by a structured rTMS intervention over several weeks. Participants will undergo both pseudo stimulation and real stimulation phases, with evaluations conducted at multiple time points to assess treatment efficacy and individual responses.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical diagnosis of Clinical High-Risk Syndrome for Psychosis
* Must be able to right-handed
* Primary school education or above
* Understand and sign a written informed consent form (jointly signed by the guardian and the participant if under 18 years old)

Exclusion Criteria:

* Major physical illnesses (organic lesions such as sensory and motor disorders, neurological disorders, and traumatic brain injury)
* Taboo symptoms for rTMS treatment (such as intracranial metal implants)
* Metal (including orthodontic treatment, dental implants) and tattoos inside the body
* Claustrophobia

Where it's running

• Shanghai Mental Health Center
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Yegang Hu, Doctor
• Email: yeganghu@126.com
• Phone: +86-21-52219305

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Mindfulness group experiences for young people at high risk for or early in psychosis

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• Biomarker changes after MT1988 dosing in young people at high risk for psychosis

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• Digital DBT for Youth at Risk of Psychosis

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• French version of the Schizophrenia Proneness Instrument for children and adolescents (SPI-CY)

  This project will test the French SPI-CY to see if it reliably identifies French-speaking adolescents (ages 12–17) who are at high risk for developing psychosis.

  Recruiting at 2 sites Centre Psychothérapique de Nancy · Lille and 2 other locations · NCT06649552

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.