Personalized rTMS treatment for individuals at high risk of psychosis
RTMS for Clinical High-risk Syndrome of Psychosis Based on Personalized Targets Using Magnetoencephalography
This study is testing a personalized brain treatment called rTMS to see if it can help people at high risk of developing psychosis feel better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 26 (estimated) |
| Ages | 13 Years to 35 Years |
| Sex | All |
| Sponsor | Shanghai Mental Health Center Academic / other |
| Locations | 1 site (Shanghai) |
| Trial ID | NCT06802952 on ClinicalTrials.gov |
What this trial studies
This study investigates the use of repetitive transcranial magnetic stimulation (rTMS) tailored to individual brain targets identified through magnetoencephalography (MEG) in patients diagnosed with Clinical High-Risk Syndrome for Psychosis. The approach involves first determining the precise locations of abnormal brain signals using MEG, followed by a structured rTMS intervention over several weeks. Participants will undergo both pseudo stimulation and real stimulation phases, with evaluations conducted at multiple time points to assess treatment efficacy and individual responses.
Who should consider this trial
Good fit: Ideal candidates are right-handed individuals with a clinical diagnosis of Clinical High-Risk Syndrome for Psychosis who have at least a primary school education.
Not a fit: Patients with major physical illnesses, contraindications for rTMS, or claustrophobia may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more effective and personalized treatment options for individuals at high risk of developing psychosis.
How similar studies have performed: While the use of rTMS is established, this specific individualized approach based on MEG targeting is novel and has not been widely tested in similar studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical diagnosis of Clinical High-Risk Syndrome for Psychosis * Must be able to right-handed * Primary school education or above * Understand and sign a written informed consent form (jointly signed by the guardian and the participant if under 18 years old) Exclusion Criteria: * Major physical illnesses (organic lesions such as sensory and motor disorders, neurological disorders, and traumatic brain injury) * Taboo symptoms for rTMS treatment (such as intracranial metal implants) * Metal (including orthodontic treatment, dental implants) and tattoos inside the body * Claustrophobia
Where this trial is running
Shanghai
- Shanghai Mental Health Center — Shanghai, China (Recruiting)
Study contacts
- Study coordinator: Yegang Hu, Doctor
- Email: yeganghu@126.com
- Phone: +86-21-52219305
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.