Personalized rTMS therapy to improve walking in Parkinson's patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of personalized repetitive transcranial magnetic stimulation (rTMS) protocols tailored to the functional reserve of patients with Parkinson's disease. By categorizing patients based on their motor and cognitive functional reserves, the study aims to compare the efficacy of these personalized protocols against conventional high-frequency rTMS applied to the primary motor cortex. The approach seeks to enhance motor function recovery by addressing the unique needs of each patient rather than using a one-size-fits-all method. Participants will be randomly assigned to different treatment groups to evaluate the outcomes of this tailored therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. patients with Parkinson's disease, diagnosed by the United Kingdom (UK) Parkinson's Disease Society Brain Bank Diagnostic Criteria,
2. Modified Hoehn and Yahr (H\&Y) scale, stage 2\~4,
3. patients who can walk on flat surfaces without the need for a gait aid,
4. aged ≥50 years old,
5. patients willing to sign the informed consent.

Exclusion Criteria:

1. those with contraindications to rTMS, such as epilepsy, implanted metal objects in the head, or a history of craniotomy,
2. those with cognitive impairment, confirmed through the Montreal Cognitive Assessment (MoCA) test as follows: \< 7 points: Illiterate \< 13 points: Education duration 0.5-3 years \< 16 points: Education duration 4-6 years \< 19 points: Education duration 7-9 years \< 20 points: Education duration 10 years or more
3. those with coexisting neurological conditions, such as spinal cord injury or Stroke,
4. those with major psychiatric disorders, such as major depression, schizophrenia, or dementia,
5. those with severe on-off phenomena or severe dyskinesia, deemed by the investigators to render participation in the study inappropriate.
6. those having contraindications to conduct an MRI study,
7. those who are pregnant or lactating,
8. patients who have refused to participate in this study.

Where it's running

• Samsung Medical Center
  Seoul, South Korea Recruiting

Study contacts

• Principal investigator: Won Hyuk Chang, PhD — Samsung Medical Center
• Study coordinator: Won Hyuk Chang, PhD
• Email: wh.chang@samsung.com
• Phone: +82-2-3410-6068

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.