Personalized rTMS therapy to improve upper limb function in stroke patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of personalized repetitive transcranial magnetic stimulation (rTMS) protocols tailored to the functional reserve of hemiplegic stroke patients in the subacute phase. By categorizing patients based on their corticospinal tract preservation, the study aims to compare the outcomes of individualized rTMS treatment against conventional low-frequency rTMS therapy. The approach is designed to enhance motor function recovery by addressing the unique needs of each patient rather than applying a one-size-fits-all protocol. The study involves screening evaluations, including motor evoked potentials and imaging techniques, to determine the most effective stimulation targets.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. hemiplegic stroke patients in the subacute phase (7 days to 3 months from the onset) who are currently hospitalized,
2. FMA score of the upper extremity ≤42,
3. adequate language and cognitive function to perform at least a 1-step obey-command,
4. pre-stroke functional level of modified Rankin Scale (mRS) ≤1,
5. aged ≥19 years old,
6. patients willing to sign the informed consent.

Exclusion Criteria:

1. those with contraindications to rTMS, such as epilepsy, implanted metal objects in the head, or a history of craniotomy,
2. those with progressive of hemodynamically unstable medical conditions,
3. those with coexisting neurological conditions, such as spinal cord injury or Parkinson's disease,
4. those with major psychiatric disorders, such as major depression, schizophrenia, or dementia,
5. those having contraindications to conduct an MRI study,
6. those who are pregnant or lactating ,
7. patients who have refused to participate in this study.

Where it's running

• Samsung Medical Center
  Seoul, South Korea Recruiting

Study contacts

• Principal investigator: Won Hyuk Chang, PhD — Samsung Medical Center
• Study coordinator: Won Hyuk Chang, PhD
• Email: wh.chang@samsung.com
• Phone: 82-2-3410-6068

Similar studies

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.