Personalized pain management for children undergoing spine surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop a personalized perioperative analgesia platform (PPAP) that links genetic factors to opioid metabolism in order to improve pain management for children undergoing posterior spinal fusion surgery. The approach involves preoperative genotyping to identify genetic variants that may predispose children to adverse effects from opioids, such as respiratory depression and opioid dependence. By tailoring opioid dosing based on these genetic insights, the study seeks to enhance pain relief and minimize complications associated with opioid use in the postoperative period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children ages 10 to 21
* ASA physical status 1 to 3
* Undergoing Posterior-Lateral Spinal Fusion
* Receives in-patient opioids
* Prescribed opioids at discharge

Exclusion Criteria:

* Serious illness
* Preoperative severe pain
* Preoperative opioid use or misuse

Where it's running

• University of California
  San Francisco, California, United States Recruiting
• Riley Children's Hospital
  Indianapolis, Indiana, United States Recruiting
• UPMC Children's Hospital
  Pittsburgh, Pennsylvania, United States Recruiting
• Children's Orthopaedic and Scoliosis Surgery Associates, LLP
  St. Petersburg, Florida, United States Not yet recruiting
• Johns Hopkins All Children's Hospital
  St. Petersburg, Florida, United States Not yet recruiting

Study contacts

• Principal investigator: Senthilkumar Sadhasivam, MD, MPH — University of Pittsburgh
• Study coordinator: Senthilkumar Sadhasivam, MD, MPH
• Email: sadhasivams@upmc.edu
• Phone: 4126472994

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Comparing two bone graft extenders for spinal fusion surgery

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.