Personalized nutritional support for elderly individuals
New Participatory Research Strategy and Multidimensional Phenotyping Towards Personalized Preventive Nutritional Support for Elderly People
This study is trying to see how different foods affect the blood sugar and metabolism of older adults aged 60 to 75, so they can create personalized diet plans to help improve their health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 250 (estimated) |
| Ages | 60 Years to 75 Years |
| Sex | All |
| Sponsor | Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement Academic / other |
| Locations | 3 sites (Clermont-Ferrand, France and 2 other locations) |
| Trial ID | NCT06163794 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the inter-individual variability in the postprandial response to food among non-dependent elderly individuals aged 60 to 75. By conducting deep phenotyping on 150 volunteers, the study will measure various parameters such as blood glucose levels, metabolic responses, and lifestyle factors to establish distinct 'metabotypes'. The goal is to develop personalized nutritional strategies that cater to the unique metabolic profiles of elderly participants, potentially improving their dietary management and overall health.
Who should consider this trial
Good fit: Ideal candidates are non-dependent men and women aged 60 to 75 with specific grip strength and BMI criteria.
Not a fit: Patients with diabetes or recent acute health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to tailored nutritional interventions that enhance health outcomes for elderly individuals.
How similar studies have performed: While the concept of personalized nutrition is gaining traction, this specific approach to deep phenotyping in the elderly is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \- Subject with grip strength (assessed with a dynamometer) ≥16kg for women and ≥26 kg for men. * 21 ≤ BMI ≤35 * Participant living in a rural or peri-urban area or city dweller, according to the population density grid of the Territorial Observatory (categories 3, 2 or 1 respectively). * Cognitively able to perform tests and answer questionnaires according to the judgment of the recruiting doctor and on the basis of the Mini-Mental State Examination (MMSE) * Available to carry out the entire protocol * Biological assessment considered by the investigator as compatible with participation in the study, * Subject agreeing to give written consent, and registration in the national file of volunteers who lend themselves to research * Person subject to a social security system. Exclusion Criteria: * \- Diabetes treated * Sub-acute pathology (flu, gastroenteritis, bacterial infection, etc.) or trauma (fracture, surgical intervention, etc.) in the 30 days preceding inclusion. * Hepatocellular insufficiency, * Heart failure with decompensation, * Renal insufficiency (clearance \<30 ml/min) * Chronic anti-inflammatory treatment, long-term corticosteroid therapy \> 1 month, infiltrations * Antibiotic treatment within 30 days prior to recruitment * Progressive pathology at the time of inclusion (cancer, etc.) * Gastrointestinal pathology deemed incompatible with the protocol * Eating habits incompatible with the protocol (allergies, test food intolerances/aversions, vegan diets, ketogenic diets, etc.) * Unstabilized thyroid diseases * Intense physical activity (activity causing shortness of breath and sweating) \> 10 hours per week * Person who is in a period of exclusion on the National File of Healthy Volunteers * Subject presenting a psychiatric pathology or cognitive disorders making them incapable of giving informed consent. * Subject under guardianship, curatorship, deprived of freedoms or under the protection of justice
Where this trial is running
Clermont-Ferrand, France and 2 other locations
- Pic / Cic-Inserm 1405 — Clermont-Ferrand, France, France (Recruiting)
- Plateforme d'Exploration de la Mobilité (CHU Clermont-Ferrand) — Clermont-Ferrand, France (Recruiting)
- Centre de Recherche en Odontologie Clinique, Faculté de Chirurgie Dentaire — Clermont-Ferrand, France (Recruiting)
Study contacts
- Principal investigator: Gisèle Pichering, Pr — Centre d'Investigation Clinique
- Study coordinator: Sergio Polakof, Ph D
- Email: sergio.polakof@inrae.fr
- Phone: +33473624895
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.