Personalized neurorehabilitation for stroke recovery
Precision Sensorimotor Neurorehabilitation Through Personalized Stimulation Loops
NA · University of Zurich · NCT06466772
This study is testing a new personalized rehab approach to help stroke survivors improve their walking by using tailored feedback and sound therapy during sleep.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Zurich (other) |
| Locations | 1 site (Zurich, Canton of Zurich) |
| Trial ID | NCT06466772 on ClinicalTrials.gov |
What this trial studies
This study focuses on improving gait recovery in stroke patients through precision neurorehabilitation. It integrates two innovative approaches: hyper-personalized feedback for lower limb motor rehabilitation and targeted auditory stimulation during sleep. The aim is to tailor rehabilitation methods to individual patient needs, addressing the variability in treatment responses. By employing these personalized techniques, the study seeks to enhance lower limb function and mobility in stroke survivors.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who have experienced an ischemic stroke or intracerebral hemorrhage with a gait deficit lasting between 30 days to 6 months.
Not a fit: Patients with significant cognitive impairment or those unable to adapt their gait voluntarily may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve mobility and quality of life for stroke patients.
How similar studies have performed: While the concept of precision neurorehabilitation is emerging, this specific combination of personalized feedback and auditory stimulation is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ischemic stroke or intracerebral hemorrhage with a gait deficit older than 30 days but not more than 6 months. * Functional Ambulation Category ≥3 * ≥18 years of age * Informed consent as documented by signature Exclusion Criteria: * Cognitive impairment, Montreal Cognitive Assessment (MoCa) \< 20 * Comprehensive aphasia precluding the understanding of study-related information * Previous stroke that caused sustained clinically relevant cognitive, visual and/or gait deficits * Expected acute hospitalization during the training period * History of a physical or neurological condition that interferes with study procedures * Social and/or personal circumstances that interfere with the ability to return for therapy sessions and follow-up assessments * Not capable of voluntary gait adaptation * Allergy to nickel * Patients taking benzodiazepines or Z-drugs with a significant effect on sleep EEG
Where this trial is running
Zurich, Canton of Zurich
- University Hospital Zurich — Zurich, Canton of Zurich, Switzerland (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Stroke