Personalized neurorehabilitation for improving gait in Parkinson's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on enhancing gait and postural stability in patients with Parkinson's disease through precision neurorehabilitation. It employs a combination of hyper-personalized feedback and targeted auditory stimulation during sleep to tailor interventions to individual patient needs. The goal is to improve lower limb function and mobility by addressing the variability in treatment responses among patients. This proof-of-concept study aims to establish structured methods for effective rehabilitation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Idiopathic Parkinson's disease with gait and postural stability deficits
* ≥18 years of age
* United Parkinson Disease Rating Scale (UPDRS) III gait scores 1-3
* UPDRS III postural instability scores 1-3
* Prescribed rehabilitation therapy at cereneo
* Informed consent as documented by signature
* Adjustments in dopaminergic medication and deep brain stimulation (DBS) to improve motor symptoms implemented to the current best possible extent

Exclusion Criteria:

* Cognitive impairment, Montreal Cognitive Assessment (MoCa) \< 20
* Comprehensive aphasia precluding the understanding of study-related information
* Other neurological or medical condition that caused sustained clinically relevant gait and/or postural stability deficits
* Expected acute hospitalization during the training period
* History of a physical or neurological condition that interferes with study procedures
* Social and/or personal circumstances that interfere with the ability to return for therapy sessions and follow-up assessments
* Not capable of voluntary gait adaptation
* Patients taking benzodiazepines or Z-drugs that have a significant effect on sleep EEG
* Recent DBS implant (≤ 6 months)
* Inability to perform outcome assessments without walking aid
* Skin disorders/problems/allergies in face/ear area that could worsen with electrode application (e.g. nickel allergy)

Where it's running

• University Hospital Zurich
  Zurich, Canton of Zurich, Switzerland Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.