Clinical trial Recruiting at 1 site Interventional Ages 18 to 60

Personalized music using the ISO principle to reduce stress, anxiety, and depression.

Official title: An ISO Principle-Based Music Intervention for Reducing Stress, Anxiety, and Depression

Run by Shanghai Mental Health Center · NCT07055061 · Data updated 2026-11-12

This project tests whether personalized playlists that gradually change musical mood (the ISO principle) can help adults experiencing work-, family-, or other-related stress, anxiety, or depression.

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Quick facts

Study typeInterventional
Ages18 Years to 60 Years
SexAll
Enrollment2000 (estimated)
SponsorShanghai Mental Health Center
Academic / other
Locations2 sites (Beijing, Beijing Municipality and 1 other locations)
StatusRecruiting
StartedApril 23, 2024
Main results expectedAugust 30, 2026
Study endsDecember 31, 2026
Registry record updatedJuly 23, 2026
Trial IDNCT07055061 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults with stress, anxiety, or depression related to work, family, or other life sources who meet the study's education requirement (at least vocational college) and do not have current psychiatric medication use, recent surgery, hearing impairments, pregnancy, or breastfeeding.

Probably not a fit

People with current psychiatric disorders, those taking psychiatric medications, individuals with hearing impairments, and pregnant or breastfeeding women are excluded and are unlikely to benefit from this intervention as tested.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial randomly assigns adults with work-, family-, or other-related stress, anxiety, or depression to receive a personalized ISO-principle music intervention or to a control condition. Intervention participants receive tailored playlists whose emotional characteristics are gradually modified to help users move toward a calmer or more desired mood, while control participants do not receive a music intervention during the same period. Outcomes are measured with self-report questionnaires of stress, emotional state, and overall well‑being at baseline and follow-up. The approach aims to develop a low-cost, non-invasive behavioral tool for emotion regulation.

Why it matters

Potential benefit: If successful, this approach could offer an accessible, non‑invasive way to reduce symptoms of stress, anxiety, and depression using personalized music playlists.

How similar studies have gone: Previous music-therapy and ISO-principle based interventions have shown promising but mixed results for mood and stress reduction in smaller trials.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

\- Minimum of a secondary specialized school degree (vocational college) or higher

Exclusion Criteria:

* Self-reported current or recent use of medication or history of surgical treatment
* Self-reported history of psychiatric disorders
* Self-reported hearing impairments
* Female participants who are self-reported currently pregnant or breastfeeding

Where it's running

  • Tsinghua University
    Beijing, Beijing Municipality, China
    Recruiting
  • The Department of Psychology of Tsinghua University
    Beijing, Beijing Municipality, China
    Completed

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.