Personalized lifestyle changes for obesity management
Phenotype-Tailored Lifestyle Intervention for Obesity: A Randomized Trial
This study is testing if a personalized lifestyle program can help adults with obesity lose weight more effectively than a standard program.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 228 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT06770049 on ClinicalTrials.gov |
What this trial studies
This study aims to create a precision medicine approach for obesity by comparing a standard lifestyle intervention program with a phenotype-tailored lifestyle intervention program. Participants will be men and women aged 18 to 65 with obesity, who will be monitored for weight loss and maintenance. The goal is to enhance the effectiveness of weight loss strategies through personalized interventions based on individual characteristics. The study is observational and will take place at the Mayo Clinic in Rochester, Minnesota.
Who should consider this trial
Good fit: Ideal candidates are men and women aged 18 to 65 with a BMI greater than 30 kg/m².
Not a fit: Patients with recent significant weight changes, untreated psychiatric disorders, or uncontrolled medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more effective weight loss strategies tailored to individual needs, improving long-term outcomes for patients with obesity.
How similar studies have performed: Other studies have shown promise in using personalized approaches for obesity management, suggesting potential success for this method.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion: • men or women between 18 to 65 years with obesity (BMI\>30kg/m2). Exclusion: * weight change greater than 3% in the previous 3 months * history of bariatric surgery and bariatric endoscopy * untreated psychiatric disorders including binge eating disorders and bulimia * current use of AOMs * history of use of medications affecting weight or energy intake or energy expenditure in the last 6 months * history of type 1 diabetes mellitus or uncontrolled medical conditions (e.g., uncontrolled hypertension) * women who are pregnant or plan to become pregnant, * any condition that limits their participation in the study * Principal Investigator discretion
Where this trial is running
Rochester, Minnesota
- Mayo Clinic — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Andres Acosta, MD,PhD — Mayo Clinic
- Study coordinator: Megan Schaefer
- Email: RSTWEIGHTLOSS@mayo.edu
- Phone: 507-266-6004
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.