Personalized electrical stimulation for emotional disorders in patients with CNS demyelination
Official title: This Study is Designed to Evaluate the Efficacy of Personalized Alternating Current Stimulation in the Treatment of Emotional Disorders in Patients With Inflammatory Demyelination of the Central Nervous System
Run by Xuanwu Hospital, Beijing · NCT06933537 · Data updated 2026-11-12
This study is testing if a new type of electrical stimulation can help people with multiple sclerosis and similar conditions feel less anxious.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 65 (estimated) |
| Sponsor | Xuanwu Hospital, Beijing Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Status | Recruiting |
| Started | December 29, 2024 |
| Main results expected | July 1, 2027 |
| Study ends | October 1, 2027 |
| Registry record updated | April 18, 2025 |
| Trial ID | NCT06933537 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 65 with inflammatory demyelinating diseases and a Hamilton Anxiety Scale score greater than 14.
✕Probably not a fit
Patients who have experienced a relapse in the past month or have undergone recent neuromodulation treatments may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of personalized alternating current stimulation in treating emotional disorders among patients diagnosed with inflammatory demyelinating diseases of the central nervous system, such as multiple sclerosis and neuromyelitis optica spectrum disorders. Participants will receive treatment using the Neuroelectrics StarStim 32 device while being monitored for changes in their emotional health. The study aims to determine if this innovative approach can alleviate anxiety symptoms in this specific patient population.
Why it matters
Potential benefit: If successful, this treatment could significantly improve emotional well-being and quality of life for patients suffering from emotional disorders related to CNS demyelination.
How similar studies have gone: While the approach of using personalized electrical stimulation is innovative, similar studies in neuromodulation for emotional disorders have shown promising results, suggesting potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients diagnosed with inflammatory demyelinating diseases of the central nervous system, such as neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) * Hamilton Anxiety Scale (HAM-A) score \> 14 * Aged between 18 and 65 years, with no gender restrictions * Receiving stable doses of immunosuppressive therapy for at least one month * Expanded Disability Status Scale (EDSS) score ≤ 6 * Right-handed * Willing to participate and sign informed consent Exclusion Criteria: * Recorded relapse within the past month * Recent medication adjustments or treatments involving modified electroconvulsive therapy, transcranial magnetic stimulation, or other neuromodulation techniques within the past month * Participation in any other clinical study within the past month or currently * Presence of cochlear implants, cardiac pacemakers, or implanted stimulators in the brain * Impaired skin integrity at the electrode placement site or allergies to electrode gel or adhesives * History of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections * Pregnant or breastfeeding women, or those planning to conceive in the near future * Hamilton Depression Scale suicide item score ≥ 3 or comorbid severe mental disorders * Presence of severe or unstable organic diseases * Poor compliance preventing cooperation with treatment, follow-up, or clinical, EEG, and imaging data collection * Any condition deemed unsuitable for study participation by the investigator
Where it's running
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Xuanwu Hospital, Capital Medical University
Beijing, Beijing Municipality, China Recruiting
Study contacts
- Study coordinator: junwei Hao, MD
- Email: haojunwei@vip.163.com
- Phone: 01083198277
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Transcranial alternating current stimulation for cognitive problems in inflammatory demyelinating CNS disorders
This trial will try transcranial alternating current stimulation to see if it improves thinking and memory in adults with multiple sclerosis and related inflammatory demyelinating central nervous system disorders.
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Personalized brain stimulation for thinking problems in inflammatory demyelinating disorders
This project will test whether personalized transcranial electrical stimulation can improve thinking and memory in adults with inflammatory demyelinating diseases such as MS and NMOSD.
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Using electrical stimulation to relieve chronic pain in patients with inflammatory demyelinating diseases
This study is testing whether a type of electrical stimulation can help relieve chronic pain in people with inflammatory demyelinating diseases.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.