Personalized electrical stimulation for cognitive impairment in demyelination patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of individualized transcranial electrical stimulation (tES) in improving cognitive function in patients with inflammatory demyelinating disorders such as Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders. Participants will undergo a one-time tES intervention, with cognitive performance assessed through standardized neuropsychological tests before and after the treatment. The study aims to measure improvements in cognitive domains including working memory, attention, executive function, and processing speed. The hypothesis is that personalized tES will lead to significant cognitive enhancements, providing a non-invasive therapeutic option for cognitive decline in these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with Neuromyelitis Optica Spectrum Disorders (NMOSD), Multiple Sclerosis (MS), and other Central Nervous System Inflammatory Demyelinating Diseases that meet diagnostic criteria;
* Patients with SDMT scores \<55 or subjective cognitive decline;
* Age between 18 and 65 years, gender unrestricted;
* No relapse or medication changes in the past month;
* EDSS (Expanded Disability Status Scale) score ≤6;
* Right-handed, native Chinese speakers with sufficient educational background to understand the test instructions; -Willing to participate and have signed informed consent.-

Exclusion Criteria:

* Relapse record within the past month;
* Medication adjustment within the past month or having undergone modified electroconvulsive therapy, transcranial magnetic stimulation, or other neuromodulation techniques;
* Participating in any other clinical research within 1 month prior to enrollment or currently;
* Presence of cochlear hearing aids, cardiac pacemakers, or implanted brain stimulation devices;
* Skin integrity damage at electrode placement sites, or allergy to electrode gel or adhesives;
* History of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections;
* Pregnant or lactating women, or those planning pregnancy in the near future;
* Scoring ≥3 on item 3 (suicide item) of the HDRS-17 or concurrent severe mental illness;
* Concurrent severe or unstable organic diseases;
* Unable to cooperate with treatment, follow-up, or clinical, EEG, and imaging data collection due to poor patient compliance;
* Other situations deemed inappropriate for study participation by the researchers.

Where it's running

• Xuanwu Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Jun wei Hao, MD
• Email: haojunwei@vip.163.com
• Phone: 010+83198277

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.