Personalized dietary advice based on metabolic responses
Official title: The NUTRIOME Meal Study - a Data-driven Precision Nutrition Intervention Study Using Meal Responses
Run by Chalmers University of Technology · NCT06842433 · Data updated 2026-11-12
This study is testing whether personalized diet plans based on how your body reacts to food can improve heart and metabolic health better than a standard healthy diet for people aged 40 to 70 who are slightly overweight.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years to 70 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Chalmers University of Technology Academic / other |
| Locations | 3 sites (Wageningen and 2 other locations) |
| Status | Recruiting |
| Started | March 14, 2025 |
| Main results expected | June 30, 2026 |
| Study ends | June 30, 2026 |
| Registry record updated | March 21, 2025 |
| Trial ID | NCT06842433 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are men and women aged 40 to 70 with a BMI between 27 and 35 who do not have a history of cardiovascular disease or diabetes.
✕Probably not a fit
Patients with diagnosed cardiovascular disease, diabetes, or certain gastrointestinal conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multi-center study aims to develop personalized dietary recommendations by analyzing metabolic responses to various dietary challenges. It will compare the effectiveness of these personalized diets against a general healthy diet based on national guidelines in improving cardio-metabolic health markers. The study will involve 120 participants aged 40 to 70 with a BMI of 27-35, who will undergo a series of meal tests to assess their metabolic responses. The research will be conducted at three sites across Sweden, Norway, and the Netherlands.
Why it matters
Potential benefit: If successful, this approach could lead to more effective dietary interventions tailored to individual metabolic responses, improving overall health outcomes.
How similar studies have gone: Other studies have shown promise in personalized nutrition approaches, suggesting potential for success in this novel intervention.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women * Age 40 to 70 years * Body mass index (BMI) 27-35 kg/m2 * Signed informed consent Exclusion Criteria: * History of diagnosed cardiovascular disease (e.g. stroke, heart disease) * Diagnosed type 1 or type 2 diabetes * Finger prick glucose test at screening indicating diabetes (fasting \>6.9 mmol/L; non-fasting \>11.0 mmol/L) * Antibiotic use in the last 3 months * Taking medication that can interfere with the planned outcome measures, as judged by the study physician (e.g. peroxisome proliferator-activated receptor-α \[PPAR-α\] or PPAR-γ agonists \[fibrates\], sulfonylureas, biguanides, α-glucosidase inhibitors, thiazolidinediones, repaglinide, nateglinide and insulin, chronic use of NSAIDs). Statins and hypertension medication are allowed if the medication regimen has been stable for the last three months * Stomach and gastrointestinal conditions (e.g. Morbus Chron, Ulcerative colitis, irritable bowel syndrome, malabsorption, colostomy, bowel resection, gastric bypass surgery etc.) * History of major gastrointestinal surgery * Anaemia: Hb concentrations \< 8.5 mmol/L for men and \< 7.5 mmol/L for women * Recent blood donation (within 2 months prior to the screening) * Recent participation in another intervention study (within 2 months prior to the screening) * Allergy or intolerance to medical skin adhesives * Chronic or acute inflammatory conditions (e.g., rheumatoid arthritis, psoriatic arthritis) * Autoimmune disorders * Thyroid disorders * Significant renal or liver dysfunction or chronic kidney or liver disease * Known food allergies/intolerances to intervention foods or food products used in the study * Following specific dietary regimen that could impact results or not suitable for the study design (e.g. vegetarian, vegan) * Habitual tobacco consumption (e.g. smoking, use of snus, vaping) * Alcohol intake ≥ 14 alcoholic beverages/week for women and ≥ 21 alcoholic beverages/week for men * Current or planned pregnancy or lactating * Other serious medical conditions that could interfere with participation or study outcomes * Unable to sufficiently understand written and spoken national language (where the study centre is located) to provide written consent and understand information and instructions from the study personnel. * Deemed unsuitable for participation in the trial, for any reason, as judged by the research physician or PI. * Working at the division conducting the trial at any of the three study centres. * Do not have a mobile phone that is suitable for the use of a research app.
Where it's running
-
Wageningen University and Research, Human research unit
Wageningen, Netherlands Recruiting -
Department of nutrition, University of Oslo
Oslo, Norway Recruiting -
University of Gothenburg, Department of Internal medicin and Clinical nutrition
Gothenburg, Sweden Recruiting
Study contacts
- Study coordinator: Rikard Landberg, PhD
- Email: rikard.landberg@chalmers.se
- Phone: +46723509386
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.