Personalized cognitive training for early psychosis
Official title: Self-administered COgnitive Personalized Training in Early Psychosis: a Randomized Controlled Trial in Adolescents and Young Adults to Assess Efficacy and Efficiency of an EHealth Application Providing Personalized Cognitive Training
Run by Centre Hospitalier St Anne · NCT06634446 · Data updated 2026-11-12
This study is testing a new mobile app that offers personalized brain training games to help young people with early psychosis improve their thinking skills and support their education and job prospects.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 16 Years to 35 Years |
| Sex | All |
| Enrollment | 240 (estimated) |
| Sponsor | Centre Hospitalier St Anne Academic / other |
| Locations | 1 site (Paris) |
| Status | Recruiting |
| Started | October 26, 2021 |
| Main results expected | December 30, 2026 |
| Study ends | December 30, 2027 |
| Registry record updated | October 10, 2024 |
| Trial ID | NCT06634446 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adolescents and young adults aged 16 to 35 who have recently been diagnosed with first episode psychosis.
✕Probably not a fit
Patients with severe medical conditions, intellectual disabilities, or those unable to participate in cognitive training due to sensorimotor deficits may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to enhance early intervention in first episode psychosis by utilizing an innovative eHealth tool that offers personalized cognitive training tailored to individual cognitive abilities. The intervention involves a mobile application designed for cognitive training, including engaging video games, to improve cognitive functions that are often neglected in early psychosis. By making cognitive remediation more accessible and youth-friendly, the study seeks to address the negative impacts of psychosis on education and employment outcomes for adolescents and young adults. Participants will be adolescents and young adults aged 16 to 35 who are newly diagnosed with an episode of psychosis.
Why it matters
Potential benefit: If successful, this approach could significantly improve cognitive functioning and quality of life for patients experiencing early psychosis.
How similar studies have gone: Previous studies have shown promise in using cognitive remediation for chronic psychosis, but this approach focusing on early intervention with personalized tools is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adolescent and young adults, both genders, aged 16 to 35, * Seeking help in one of the recruiting centers, * Newly diagnosed as experiencing an Episode of Psychosis (reaching criteria as described in the Comprehensive Assessment of at Risk Mental States (CAARMS) within the year * Written informed consent signed (and from one legal guardian for minors). Exclusion Criteria: * Severe and unstabilized medical conditions, * Insufficient level in reading and/or French language, * Absence of medical insurance, * Participation in another intervention trial, * Enforced hospitalization (ASPDT, ASPPI, ASPRE), * Intellectuel Deficiency (IQ\<70), and / or sensorimotor deficits incompatible with the cognitive training,
Where it's running
-
Groupe Hospitalier Universitaire Paris - Psychiatrie et Neurosciences, (GHU Paris)
Paris, France Recruiting
Study contacts
- Principal investigator: Marie Odile MO KREBS, PROFESSEUR — GHU PARIS Saint-Anne
- Study coordinator: Marie Odile KREBS, PROFESSEUR
- Email: MO.KREBS@ghu-paris.fr
- Phone: +331 456 586 46
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
French Minds: a French, Multimodal Cohort Study of Severe Psychiatric Disorders and Healthy Controls
This study tests whether people with mood, psychotic, or autism disorders can be grouped into more similar subtypes based on social withdrawal and anhedonia, across ages 15 to 60.
-
Enhancing cognitive self-management to improve work and school outcomes in first-episode psychosis
This pilot study tests whether adding a cognitive self-management program to standard employment and education services helps young adults with first-episode psychosis find and stay in work or school.
-
Thinking and brain chemistry in early psychosis
This study will test whether a short session of gentle electrical brain stimulation changes glutamate levels and helps working memory and attention in people who recently experienced psychosis.
-
Psychoeducation Program for Family Caregivers Coordinated by an APRN
A program led by an advanced practice nurse tests whether structured family psychoeducation can reduce the burden on caregivers of people with a first episode of psychosis.
-
Reducing the Time to Start Treatment for First Episode Psychosis through Screenings and Clearer Information
This study tests whether a systematic screening approach plus a clear communication model (ComPsych) can shorten the time from onset to specialty care for people at high risk or experiencing first episode psychosis.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.