Personalized cancer treatment based on tumor molecular profiling
Official title: Individualized Molecular Profiling for Allocation to Clinical Trials (IMPACT) Project
Run by National Cancer Centre, Singapore · NCT02806388 · Data updated 2026-11-12
This study is testing whether analyzing the genetic makeup of a person's tumor can help doctors choose the best cancer treatment for them.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 12 Years and up |
| Sex | All |
| Enrollment | 5500 (estimated) |
| Sponsor | National Cancer Centre, Singapore Academic / other |
| Locations | 1 site (Singapore) |
| Status | Recruiting |
| Started | October 2011 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2027 |
| Registry record updated | May 13, 2026 |
| Trial ID | NCT02806388 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals with a confirmed diagnosis of solid tumors who are suitable for systemic treatment and clinical trials.
✕Probably not a fit
Patients who do not have a solid tumor or those who are not eligible for systemic treatment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project focuses on screening the molecular profile of tumors to enhance the selection of anticancer treatments, particularly for allocation to available clinical trials. It involves collecting archival or freshly obtained tumor tissue, as well as blood, pleural fluid, fine needle aspirates, and saliva to analyze the genetic makeup of the tumor. The goal is to provide personalized therapy tailored to the individual molecular profile of the patient’s tumor.
Why it matters
Potential benefit: If successful, this approach could lead to more effective and targeted cancer treatments for patients.
How similar studies have gone: Other studies utilizing molecular profiling for personalized cancer treatment have shown promising results, indicating potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Confirmed histological diagnosis of solid tumor * Suitable for systematic treatment and clinical trials * ECOG (Eastern cooperative oncology group) performance status \< 2 * Able to provide tumor tissue for molecular profiling * Able to understand and sign the informed consent form Exclusion Criteria: * None
Where it's running
-
National Cancer Centre, Singapore
Singapore, Singapore Recruiting
Study contacts
- Principal investigator: Daniel SW Tan — National Cancer Centre, Singapore
- Study coordinator: Daniel SW Tan
- Email: daniel.tan.s.w@singhealth.com.sg
- Phone: +65 6436 8000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.