Personalized breathing support during laparoscopic weight loss surgery
Effects of Individualized Positive End-Expiratory Pressure (PEEP) on Oxygenation, Hemodynamic Variables, and Incidence of Early Postoperative Atelectasis in Patients Undergoing Laparoscopic Bariatric Surgery: A Prospective Randomized Controlled Study
This study is testing whether adjusting breathing support for each patient during weight loss surgery can help improve their lung function and reduce complications after the operation.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 21 Years to 60 Years |
| Sex | All |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta, El-Gharbia) |
| Trial ID | NCT06115668 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of individualized positive end-expiratory pressure (PEEPIND) titration compared to a fixed PEEP of 5 cmH2O in obese patients undergoing laparoscopic bariatric surgery. The focus is on improving oxygenation, hemodynamic stability, and reducing early postoperative complications such as atelectasis. By tailoring PEEP to each patient's needs, the study aims to enhance lung function and minimize respiratory issues during and after surgery. The trial will involve monitoring various respiratory and hemodynamic parameters throughout the procedure.
Who should consider this trial
Good fit: Ideal candidates are obese patients aged 21 to 60 scheduled for elective laparoscopic bariatric surgery with ASA physical status class I-III.
Not a fit: Patients with chronic respiratory conditions, heart failure, or those who are pregnant will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce postoperative complications and improve recovery outcomes for obese patients undergoing bariatric surgery.
How similar studies have performed: While the use of PEEP in surgical settings is established, the individualized approach in this specific context is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 21 to 60 years. * Both sexes. * American Society of Anesthesiologists (ASA) physical status class I-III * Patients who are scheduled for elective laparoscopic bariatric surgery under general anesthesia. Exclusion Criteria: * Patients who are unwilling to participate in the study * Actively smokers. * Patients who had a history of Chronic obstructive pulmonary disease or bronchial asthma. * Patients who are receiving renal replacement therapy prior to surgery. * Patients who had a history of heart failure. * Pregnant. * Patients who have allergies to any drug used in the study.
Where this trial is running
Tanta, El-Gharbia
- Tanta University — Tanta, El-Gharbia, Egypt (Recruiting)
Study contacts
- Study coordinator: Heba Z Khattab, Master
- Email: hebazakaria194@gmail.com
- Phone: 00201004774825
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.