Personalized breast cancer screening based on individual risk factors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates a personalized approach to breast cancer screening by comparing traditional annual mammograms for women aged 40 and older with a more tailored screening strategy based on individual risk assessments. Participants will complete a health questionnaire and provide a saliva sample for genetic testing, which will inform their screening advice. The goal is to reduce unnecessary treatments and false-positive results while maintaining effective cancer detection rates. The study aims to address the ongoing debate regarding the effectiveness of current screening guidelines and explore the potential benefits of individualized screening.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Female\*
2. Age 30 years to 74 years old\*\*
3. Reside in the United States\*\*\*

NOTE\*: As of 2019, we are now enrolling all persons who identify as female, and will capture both their sex at birth and gender identity in the baseline survey.

NOTE\*\*: Eligibility from 2016 - October 2023 included ages 40-74 (WISDOM 1.0) and expanded to age 30 in October 2023 (WISDOM 2.0).

NOTE\*\*\*: As of 2019, recruitment is available nationwide. Original eligibility was limited to California, North Dakota, South Dakota, Iowa, Minnesota, Alabama, Louisiana, Illinois OR have coverage from a participating health plan.

Exclusion Criteria:

1. Prior Breast cancer or ductal carcinoma in situ (DCIS) diagnosis
2. Prior prophylactic bilateral mastectomy
3. Inability to provide consent
4. Non-English or Spanish proficiency (Spanish participation available: June 2019)

Where it's running

• University of Alabama at Birmingham
  Birmingham, Alabama, United States Recruiting
• University of California Irvine
  Irvine, California, United States Recruiting
• University of California Los Angeles
  Los Angeles, California, United States Recruiting
• University of California Davis
  Sacramento, California, United States Recruiting
• University of California San Diego
  San Diego, California, United States Recruiting
• University of California San Francisco
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Laura Esserman, MD, MBA — University of California, San Francisco
• Study coordinator: Allison Fiscalini, MPH
• Email: allison.stoverfiscalini@ucsf.edu
• Phone: (415) 476-0267

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.