Personalized anticoagulant therapy for pulmonary thromboembolism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the factors affecting the efficacy and safety of anticoagulant therapy in patients with pulmonary thromboembolism, particularly focusing on older adults, those with renal insufficiency, and individuals with active malignancies. The study will analyze real-world data to identify influencing factors and develop a predictive model using machine learning to forecast bleeding events and recurrence of venous thromboembolism. Participants will receive standard diagnostic and therapeutic measures as per clinical guidelines, including anticoagulant treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 18 years old;
2. Adult patients with objectively diagnosed pulmonary thromboembolism (PTE) (with or without concomitant deep vein thrombosis);
3. Specific populations meeting any of the following criteria: elderly patients (≥75 years old); patients with impaired kidney function (creatinine clearance estimated by the Cockcroft-Gault formula, CrCl \< 60ml/min); patients with active malignancies (under treatment or with unrecovered malignancies);
4. Patients who have not started anticoagulant therapy before enrollment and are planned for anticoagulant treatment after evaluation by the attending physician;
5. Ecpected life expectancy longer than 3 months.
6. Patients who understand and agree to participate in this study, sign the informed consent form, and adhere to regular follow-up visits.

Exclusion Criteria:

1. Moderate or severe liver dysfunction (Child-Pugh class B or C);
2. Spontaneous bleeding tendency, such as coagulation disorders or thrombocytopenia (PLT\<20×10\^9/L);
3. Contraindications to anticoagulant drugs, including allergy to anticoagulants, clinically significant active bleeding, significant risk of major bleeding due to lesions or conditions, significantly abnormal coagulation function, liver disease with clinically relevant bleeding risk, thrombocytopenia, etc., as determined by the attending physician;
4. High-risk pulmonary embolism requiring thrombolysis;
5. Patients currently participating in other clinical trials.

Where it's running

• Xiangya Hospital
  Changsha, Hunan, China Recruiting

Study contacts

• Principal investigator: Pengbo Deng, MD — Xiangya Hospital of Central South University
• Study coordinator: Pengbo Deng, MD
• Email: yogurt1015@163.com
• Phone: +8613574888840

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Hospital-level care delivered at home for acutely ill adults

  This trial tries to deliver hospital-level care at home to adults with sudden illnesses like infections, heart failure, COPD, asthma, or gout flares to see if it's as safe, improves patient experience, and lowers costs.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT03524222

• Using bedside electrical impedance tomography to detect pulmonary hypertension

  We will test whether a non-invasive bedside scan called electrical impedance tomography (EIT) can detect pulmonary hypertension in adults who are already having a right heart catheterization.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07453017

• Catheter ablation plus LAAC vs anticoagulation in frail elderly A-fib patients

  This study tests whether adding left atrial appendage closure to ablation is as good as using long-term blood thinners in frail people aged 75 and up with atrial fibrillation.

  Recruiting Guangdong Provincial People's Hospital · Guangzhou, Guangdong · NCT07441382

• Identifying low-risk cancer patients with pulmonary embolism for early discharge from the emergency department

  This study is trying to find out which cancer patients with pulmonary embolism can safely go home early from the emergency department to avoid extra hospital time.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna · NCT06761144

• Effects of California grapes on gut and heart health in overweight adults

  This study is testing whether eating freeze-dried grape powder can improve gut and heart health in overweight adults aged 45-70.

  Recruiting University of California, Davis · Davis, California · NCT06544954

• Smart technology for patient-centered care in pulmonary embolism

  A smartphone-based program using wearable tech and AI will help people with pulmonary embolism manage their health and see if it improves long-term outcomes.

  Recruiting Navy General Hospital, Beijing · Beijing, Beijing Municipality · NCT06382038

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.