Personalized AML: Find biomarkers to predict response to venetoclax

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will collect bone marrow samples from about 420 AML patients to analyze genomic and transcriptomic differences at the single-cell level. They will perform bulk genotyping at diagnosis and relapse, single-cell RNA sequencing, and spatial transcriptomics in a subset to identify markers linked to treatment response and chemoresistance. Data from clinical and laboratory parameters will be integrated to refine genomic subgroups with prognostic relevance. The goal is to improve patient stratification and guide more personalized treatment approaches, particularly around venetoclax therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* AML diagnosis

Exclusion Criteria:

* any condition that can interfere with the protocol or with the informed consent subscription

Where it's running

• Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Haematology Unit
  Milan, Italy Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.