Personalized aerobic exercise training for heart disease patients
Domain-specific Aerobic Exercise Training in Coronary Artery Disease
This study is testing whether personalized exercise training at different intensity levels can help people with coronary artery disease improve their fitness and health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 105 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Western University, Canada Academic / other |
| Locations | 1 site (London, Ontario) |
| Trial ID | NCT06143332 on ClinicalTrials.gov |
What this trial studies
This clinical trial focuses on improving aerobic fitness in patients with coronary artery disease (CAD) through personalized exercise training. A total of 105 participants will be randomly assigned to one of three training intensity levels: moderate, heavy, or severe. The study will assess participants' physiological and health metrics at baseline and after 7 and 14 weeks of training, which will occur three times a week on a cycle ergometer. The goal is to determine the effectiveness of tailored exercise intensity in enhancing fitness and overall health outcomes for CAD patients.
Who should consider this trial
Good fit: Ideal candidates are patients with coronary artery disease who have been cleared for structured exercise and do not have significant left ventricular dysfunction or other contraindications.
Not a fit: Patients with diagnosed heart failure, severe aortic stenosis, or major arrhythmias may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved aerobic fitness, better quality of life, and reduced hospitalizations for patients with coronary artery disease.
How similar studies have performed: While personalized exercise training has shown promise in other contexts, this specific approach in cardiac rehabilitation is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with CAD who do not have any identified left ventricular dysfunction (i.e., left ventricular ejection fraction \[LVEF\] \<50%) and who: were discharged from the hospital following admission for acute coronary syndrome (i.e., ST-elevation or non ST-elevation myocardial infarction, addressed with PCI or CABG, as documented by their attending physician; referred to St. Joseph's CRSP Program; completed a CPET at the St. Joseph's CRSP Program (as routine screening for cardiac rehabilitation) and have been cleared to exercise in a structured format (i.e., do not exhibit any contraindications to maximal exercise); without: respiratory or musculoskeletal issues that would prohibit them from cycling exercise. Exclusion Criteria: * Those who have: diagnosed heart failure, severe aortic stenosis, congenital coronary abnormality, 2-3° atrioventricular block, major arrhythmias such as atrial fibrillation (including paroxysmal), or are scheduled to undergo PCI or CABG surgery within 2 months following hospital discharge; are using insulin for diabetes; diagnosed with respiratory disease; or musculoskeletal issues that prohibit cycling exercise; and/or are unable to provide informed consent..
Where this trial is running
London, Ontario
- The University of Western Ontario — London, Ontario, Canada (Recruiting)
Study contacts
- Study coordinator: Daniel A Keir, PhD
- Email: dkeir@uwo.ca
- Phone: 519-661-2111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.