Personalized ablation strategies for atrial fibrillation
Official title: Developing Dynamic Substrate Targeted Personalised Treatment Strategies in AF.
Run by Barts & The London NHS Trust · NCT05633303 · Data updated 2026-11-12
This study is testing personalized treatment plans for people with persistent atrial fibrillation to see if tailored catheter ablation can improve their heart rhythm and treatment success.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 160 (estimated) |
| Sponsor | Barts & The London NHS Trust Academic / other |
| Locations | 1 site (London) |
| Status | Recruiting |
| Started | October 14, 2022 |
| Main results expected | October 10, 2027 |
| Study ends | October 10, 2027 |
| Registry record updated | May 8, 2026 |
| Trial ID | NCT05633303 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients with persistent atrial fibrillation lasting less than 24 months who have not previously undergone left atrial ablation.
✕Probably not a fit
Patients who are unwilling to consent, under 18 years old, or have contraindications for catheter ablation will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates personalized catheter ablation strategies for patients with atrial fibrillation (AF) by examining the underlying mechanisms that contribute to persistent AF. It aims to develop techniques to measure rate-dependent conduction velocity (RDCV) slowing and assess the impact of autonomic modulation on AF dynamics. Patients undergoing catheter ablation for persistent AF will be included, and their treatment will be tailored based on the presence of low voltage zones in the heart. The study is conducted at the Barts Heart Centre, focusing on improving the success rates of AF ablation procedures.
Why it matters
Potential benefit: If successful, this approach could lead to higher success rates in eliminating atrial fibrillation for patients undergoing catheter ablation.
How similar studies have gone: While there have been studies on catheter ablation for AF, this specific approach focusing on personalized strategies based on underlying mechanisms is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing catheter ablation for persistent AF (\<24 months AF duration and no previous left atrial ablation). * Able to provide informed consent Exclusion Criteria: * Unwillingness to sign consent * Age \<18 years * Contraindications for catheter ablation procedure
Where it's running
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Barts Heart Centre, Barts Health NHS trust
London, United Kingdom Recruiting
Study contacts
- Study coordinator: Shohreh Honarbakhsh, MRCP, BSc, PhD
- Email: shohreh.honarbakhsh@nhs.net
- Phone: 020 3765 8682
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.