Personalized 8-week program to support healthier aging with exercise, lifestyle coaching, and targeted supplements
PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)
This program will try a personalized 8-week mix of supervised exercise, sleep and diet coaching, motivational support, and supplements (whey protein, creatine, NMN, fucoidan, multivitamin) for adults aged 50–80 with below-average fitness or cognitive scores.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 50 Years to 80 Years |
| Sex | All |
| Sponsor | National University of Singapore Academic / other |
| Locations | 1 site (Singapore, Singapore) |
| Trial ID | NCT07451496 on ClinicalTrials.gov |
What this trial studies
This interventional program delivers an individualized, multimodal geromedicine package over eight weeks, combining supervised exercise and exergaming with sleep and dietary counseling, motivational interviewing, and targeted supplements. Participants are adults 50–80 who are relatively healthy but untrained and score below the 75th percentile for VO₂peak and cognitive tests. The protocol tailors interventions to baseline diagnostics and adapts based on participant response while tracking muscle, cognitive, immune, clinical, biological, and digital biomarkers. The main aims are to test feasibility and to detect short-term improvements in functional and biological markers of aging.
Who should consider this trial
Good fit: Ideal candidates are English-literate adults 50–80 who are relatively healthy but untrained, have VO₂peak and cognitive performance below the 75th percentile, can attend all visits at the MD11 Clinical Research Centre in Singapore, and can follow exercise and supplement protocols.
Not a fit: People with major cardiovascular disease, more than two unstable chronic conditions, recent major medication changes, those already engaged in regular resistance or aerobic training, or those outside the age/location requirements are unlikely to benefit from this program.
Why it matters
Potential benefit: If successful, the approach could slow early functional decline and improve muscle, cognitive, and immune markers to help prolong healthy years in middle-aged and older adults.
How similar studies have performed: Individual components like resistance exercise, protein and creatine supplementation, and lifestyle coaching have shown benefits in prior studies, but combining them into a personalized geroscience intervention of this type remains relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 50-80 years (both male and female) * Relatively healthy and in stable health condition * Not engaged in regular resistance or aerobic training in the past 12 months (i.e., untrained) * VO₂peak below the 75th percentile for age- and sex-specific norms * Cognitive performance below 75th percentile on the NIH Toolbox Cognitive Function Battery * Willing and able to comply with exercise and supplementation protocols * English-literate (can read and understand English) * Provides written informed consent * Deemed to have mental capacity, as assessed by the Principal Investigator * Are able to attend all research visits for screening and research data collection at MD11, Yong Loo Lin School of Medicine, National University of Singapore Exclusion Criteria: * Significant change in medication in the past 3 months * History of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke) * More than two unstable chronic conditions (e.g., hypertension, diabetes, osteoarthritis, COPD) * Known allergies to soy, shellfish/seaweed, mushrooms, or supplement ingredients * Participation in another interventional clinical trial * Current use of any study-related supplement unless willing to stop * Any medical, psychiatric, or cognitive condition deemed by the PI to jeopardise safety or compliance * Pregnant or planning pregnancy during the study period * Any conditions deemed by PI that jeopardize the safety or study compliance
Where this trial is running
Singapore, Singapore
- MD11 Clinical Research Centre, #03-01, 10 Medical Drive, Singapore 117597 — Singapore, Singapore, Singapore (Recruiting)
Study contacts
- Principal investigator: Prof. Andrea Britta Maier, MD, PhD — National University of Singapore
- Study coordinator: Ajla Hodzic Kuerec, MD, PhD
- Email: ahkuerec@nus.edu.sg
- Phone: +65 91686091
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.