Personalized 8-week program to support healthier aging with exercise, lifestyle coaching, and targeted supplements

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional program delivers an individualized, multimodal geromedicine package over eight weeks, combining supervised exercise and exergaming with sleep and dietary counseling, motivational interviewing, and targeted supplements. Participants are adults 50–80 who are relatively healthy but untrained and score below the 75th percentile for VO₂peak and cognitive tests. The protocol tailors interventions to baseline diagnostics and adapts based on participant response while tracking muscle, cognitive, immune, clinical, biological, and digital biomarkers. The main aims are to test feasibility and to detect short-term improvements in functional and biological markers of aging.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 50-80 years (both male and female)
* Relatively healthy and in stable health condition
* Not engaged in regular resistance or aerobic training in the past 12 months (i.e., untrained)
* VO₂peak below the 75th percentile for age- and sex-specific norms
* Cognitive performance below 75th percentile on the NIH Toolbox Cognitive Function Battery
* Willing and able to comply with exercise and supplementation protocols
* English-literate (can read and understand English)
* Provides written informed consent
* Deemed to have mental capacity, as assessed by the Principal Investigator
* Are able to attend all research visits for screening and research data collection at MD11, Yong Loo Lin School of Medicine, National University of Singapore

Exclusion Criteria:

* Significant change in medication in the past 3 months
* History of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke)
* More than two unstable chronic conditions (e.g., hypertension, diabetes, osteoarthritis, COPD)
* Known allergies to soy, shellfish/seaweed, mushrooms, or supplement ingredients
* Participation in another interventional clinical trial
* Current use of any study-related supplement unless willing to stop
* Any medical, psychiatric, or cognitive condition deemed by the PI to jeopardise safety or compliance
* Pregnant or planning pregnancy during the study period
* Any conditions deemed by PI that jeopardize the safety or study compliance

Where it's running

• MD11 Clinical Research Centre, #03-01, 10 Medical Drive, Singapore 117597
  Singapore, Singapore, Singapore Recruiting

Study contacts

• Principal investigator: Prof. Andrea Britta Maier, MD, PhD — National University of Singapore
• Study coordinator: Ajla Hodzic Kuerec, MD, PhD
• Email: ahkuerec@nus.edu.sg
• Phone: +65 91686091

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.