Personality change program for people with borderline personality disorder

Engaging Higher-Order Mechanisms of Psychopathology: a Parsimonious Approach to Precision Medicine

Not applicable Interventional University of Kentucky · NCT06005129

This study is testing a new therapy program to see if it can help people with borderline personality disorder feel better after six weekly sessions.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment30 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Kentucky Academic / other
Locations1 site (Lexington, Kentucky)
Trial IDNCT06005129 on ClinicalTrials.gov

What this trial studies

This study involves participants with borderline personality disorder undergoing a baseline assessment for 2 to 4 weeks to evaluate their condition without treatment. Following this period, participants will receive six weekly sessions of personality-based therapy lasting 50-60 minutes each. After completing the treatment sessions, there will be a 4-week follow-up to assess the sustainability of the treatment outcomes.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals who are fluent in English and have a diagnosis of borderline personality disorder.

Not a fit: Patients with other psychological conditions that require different treatments, those currently in psychotherapy, or individuals with unstable medication or substance use disorders may not benefit from this study.

Why it matters

Potential benefit: If successful, this program could lead to significant improvements in the emotional and psychological well-being of patients with borderline personality disorder.

How similar studies have performed: While there have been various approaches to treating borderline personality disorder, the specific personality-based therapy being tested in this study may offer a novel perspective.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Speak English fluently
* Diagnosis of Borderline Personality Disorder

Exclusion Criteria:

* diagnosed psychological conditions that would be better addressed by alternative treatments
* concurrent psychotherapy
* medication instability
* substance use disorder

Where this trial is running

Lexington, Kentucky

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Borderline Personality Disorder
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.