Peripheral magnetic stimulation effects on motor‑cortex excitability in healthy adults
Effects of Peripheral Magnetic Stimulation on Cortical Excitability in Healthy Individuals
This project will try different peripheral magnetic stimulation settings to see if they change motor‑cortex excitability in healthy adults aged 18–40.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 18 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Sponsor | Universidade Federal de Pernambuco Academic / other |
| Locations | 1 site (Recife, Pernambuco) |
| Trial ID | NCT07025759 on ClinicalTrials.gov |
What this trial studies
In a randomized, double‑blind crossover design, healthy right‑handed adults receive nine single‑session peripheral magnetic stimulation (rPMS) protocols over the extensor carpi radialis muscle that vary frequency (1, 10, 25 Hz) and intensity (90%, 100%, 110% of resting motor threshold). Cortical excitability is measured before and after each session using motor‑evoked potentials (MEPs) and intracortical inhibition/facilitation (ICI/ICF). The crossover design allows within‑subject comparison of parameter effects, and outcomes will be analyzed with ANOVA or nonparametric equivalents. Results aim to define which rPMS parameters produce reliable short‑term modulation of motor cortical activity.
Who should consider this trial
Good fit: Ideal candidates are healthy, right‑handed adults aged 18–40 without neurological or musculoskeletal disorders, with females using consistent contraception as required by the protocol.
Not a fit: People who are pregnant, have a history of seizures or epilepsy, metallic implants in the head/spine/face/heart, or active neurological/musculoskeletal conditions would be excluded and unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the findings could identify rPMS settings that guide non‑invasive rehabilitation approaches to modulate neural activity in neurological conditions.
How similar studies have performed: Previous small studies of peripheral magnetic stimulation have reported short‑term changes in cortical excitability, but comprehensive mapping of frequency and intensity parameters remains limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: Healthy adults aged 18-40 years, both sexes, right-handed (confirmed via Edinburgh Handedness Inventory), and for females, consistent use of contraceptive medication to mitigate hormonal influences on nervous system excitability. Exclusion criteria: Pregnancy; history of seizures or epilepsy; metallic implants in the head, spine, face, or heart; diagnosed neurological or musculoskeletal conditions interfering with assessments or interventions; or use of substances altering nervous system excitability.
Where this trial is running
Recife, Pernambuco
- Universidade Federal de Pernambuco — Recife, Pernambuco, Brazil (Recruiting)
Study contacts
- Study coordinator: Kátia Monte-Silva
- Email: lana.ufpe@gmail.com
- Phone: +55 81 21267579
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.