Peripheral magnetic stimulation effects on motor‑cortex excitability in healthy adults
Official title: Effects of Peripheral Magnetic Stimulation on Cortical Excitability in Healthy Individuals
Run by Universidade Federal de Pernambuco · NCT07025759 · Data updated 2026-11-12
This project will try different peripheral magnetic stimulation settings to see if they change motor‑cortex excitability in healthy adults aged 18–40.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 40 Years |
| Sex | All |
| Enrollment | 18 (estimated) |
| Sponsor | Universidade Federal de Pernambuco Academic / other |
| Locations | 1 site (Recife, Pernambuco) |
| Status | Recruiting |
| Started | October 1, 2022 |
| Main results expected | September 2025 |
| Study ends | October 2025 |
| Registry record updated | June 17, 2025 |
| Trial ID | NCT07025759 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy, right‑handed adults aged 18–40 without neurological or musculoskeletal disorders, with females using consistent contraception as required by the protocol.
✕Probably not a fit
People who are pregnant, have a history of seizures or epilepsy, metallic implants in the head/spine/face/heart, or active neurological/musculoskeletal conditions would be excluded and unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In a randomized, double‑blind crossover design, healthy right‑handed adults receive nine single‑session peripheral magnetic stimulation (rPMS) protocols over the extensor carpi radialis muscle that vary frequency (1, 10, 25 Hz) and intensity (90%, 100%, 110% of resting motor threshold). Cortical excitability is measured before and after each session using motor‑evoked potentials (MEPs) and intracortical inhibition/facilitation (ICI/ICF). The crossover design allows within‑subject comparison of parameter effects, and outcomes will be analyzed with ANOVA or nonparametric equivalents. Results aim to define which rPMS parameters produce reliable short‑term modulation of motor cortical activity.
Why it matters
Potential benefit: If successful, the findings could identify rPMS settings that guide non‑invasive rehabilitation approaches to modulate neural activity in neurological conditions.
How similar studies have gone: Previous small studies of peripheral magnetic stimulation have reported short‑term changes in cortical excitability, but comprehensive mapping of frequency and intensity parameters remains limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: Healthy adults aged 18-40 years, both sexes, right-handed (confirmed via Edinburgh Handedness Inventory), and for females, consistent use of contraceptive medication to mitigate hormonal influences on nervous system excitability. Exclusion criteria: Pregnancy; history of seizures or epilepsy; metallic implants in the head, spine, face, or heart; diagnosed neurological or musculoskeletal conditions interfering with assessments or interventions; or use of substances altering nervous system excitability.
Where it's running
-
Universidade Federal de Pernambuco
Recife, Pernambuco, Brazil Recruiting
Study contacts
- Study coordinator: Kátia Monte-Silva
- Email: lana.ufpe@gmail.com
- Phone: +55 81 21267579
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.