Perioperative stress control with L-tyrosine for outpatient inguinal hernia surgery
Perioperative Stress Management in Outpatient Surgery With L-tyrosine Supplementation
This trial tests whether taking L-tyrosine around the time of outpatient inguinal hernia repair can reduce perioperative stress for adult patients under general anesthesia.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Monaco) |
| Trial ID | NCT05782829 on ClinicalTrials.gov |
What this trial studies
Adults scheduled for unilateral or bilateral inguinal hernia repair under general anesthesia at a single center will receive either L-tyrosine supplementation or a matching placebo around the time of surgery. The intervention is given with the goal of improving the body's stress response without affecting wakefulness or the ability to go home after outpatient surgery. Outcomes will focus on perioperative stress levels, immediate recovery quality, and safety measures related to anesthesia and discharge. Patients with major comorbidities, significant smoking history, or psychiatric disorders are excluded per protocol.
Who should consider this trial
Good fit: Adults (≥18 years) who can consent, have social security or equivalent, and are scheduled for unilateral or bilateral inguinal hernia repair under general anesthesia are ideal candidates.
Not a fit: Patients with a history of psychiatric illness, ASA class 3–4, heavy smoking (>35 pack-years), or those having additional procedures are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, this approach could lower perioperative stress and simplify recovery and discharge for patients having outpatient hernia repair.
How similar studies have performed: Some prior work suggests L-tyrosine can reduce stress reactivity in other settings, but its use specifically in outpatient perioperative care is limited and not well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Membership of a social security scheme or equivalent * At least 18 years of age * Able to express consent * Indication of unilateral or bilateral inguinal hernia cure * General anaesthesia proposed and retained for inguinal hernia treatment regardless of surgical technique Exclusion Criteria: * Surgical indication for another reason or hernial cure associated with another procedure * Smoking estimated at more than 35 pack-years * History of psychiatric pathology * ASA 3 or 4 according to the American Society of Anesthesiologists classification. As a reminder, an ASA 3 class concerns a patient with a severe but not disabling general disease, and an ASA 4 class concerns a patient with a disabling general disease involving the vital prognosis. * ASA 2 and having at least one of the following pathologies or patients treated with -blockers: insulin-dependent diabetes, high blood pressure, heart rhythm disorder, dysthyroidism, progressive neurological disease, long-term benzodiazepines. * Starch allergy or intolerance
Where this trial is running
Monaco
- Chpg — Monaco, Monaco (Recruiting)
Study contacts
- Study coordinator: Bertrand PRUNET, PU-PH
- Email: bertrand.prunet@chpg.mc
- Phone: +377 97 98 98 19
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.