Perioperative EEG variability and risk of postoperative delirium

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study records preoperative and intraoperative electroencephalogram (EEG) data from patients aged 65 and older undergoing general anesthesia with a single-lumen endotracheal tube. Multiscale entropy analysis will be applied to EEG signals to compare temporal complexity between patients who develop postoperative delirium and those who do not. Key exclusions include severe organ dysfunction, psychiatric or communication barriers, cardiac or neurosurgical procedures, recent sedative or opioid use, low hemoglobin, and recent participation in other clinical research. The aim is to find EEG-based signatures that could enable earlier recognition of postoperative delirium.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients undergoing general anaesthesia with single-lumen endotracheal tube placement;
2. Age ≥65 years, gender unrestricted, body mass index (BMI) 18-28 kg/m²;
3. Normal mouth opening and head/neck mobility;
4. Pre-anaesthesia American Society of Anaesthesiologists (ASA) physical status classification of I or II and Mallampati airway classification of I or II.

Exclusion Criteria:

1. Individuals with psychiatric disorders, literacy issues, or communication difficulties who are unable to cooperate with POD screening;
2. Patients with severe lesions in vital organs, such as the heart, lungs, brain, liver or kidneys.
3. Those undergoing cardiac or neurosurgical procedures during this admission;
4. A history of alcohol abuse or recent use of sedatives or opioids;
5. haemoglobin \<100 g/L;
6. Participation in any clinical research studies within the past 3 months.

Where it's running

• Department of Anesthesiology,the Second Affiliated Hospital of Hainan Medical University
  Haikou, China Recruiting

Study contacts

• Study coordinator: Fu Dr.chen
• Email: Dr_chen1699@163.com
• Phone: 8617378224751

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.