Perineural dextrose versus local anesthetic injections for knee osteoarthritis
Official title: A Prospective Evaluation of the Clinical Effectiveness of Perineural Dextrose and Conventional Local Anesthetic Injections in Patients With Symptomatic Knee Osteoarthritis
Run by Ankara Training and Research Hospital · NCT07381621 · Data updated 2026-11-12
This study will test whether perineural 5% dextrose or perineural local anesthetic injections better reduce pain and improve function in adults aged 40–65 with symptomatic knee osteoarthritis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 40 Years to 65 Years |
| Sex | All |
| Enrollment | 86 (estimated) |
| Sponsor | Ankara Training and Research Hospital Academic / other |
| Locations | 2 sites (Ankara, Altindag and 1 other locations) |
| Status | Recruiting |
| Started | February 2, 2026 |
| Main results expected | November 1, 2026 |
| Study ends | November 1, 2026 |
| Registry record updated | September 9, 2026 |
| Trial ID | NCT07381621 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 40 to 65 years old with a clinical or radiological diagnosis of symptomatic knee osteoarthritis of at least three months' duration who can provide informed consent and attend follow-up visits.
✕Probably not a fit
Patients with prior knee surgery, recent intra‑articular injections, inflammatory rheumatic disease, severe systemic or neurological disease, or who are pregnant or breastfeeding are excluded and unlikely to benefit from these perineural injections.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational cohort in a routine clinical setting comparing patients who receive perineural 5% dextrose injections or perineural local anesthetic injections as part of usual care. Treatment choice is determined by clinician judgment and patient preference rather than randomization. Participants will be followed for six months with outcome measures at baseline and at 1, 3, and 6 months. Outcomes include pain measured by VAS, function by WOMAC, knee range of motion by goniometry, and quadriceps strength.
Why it matters
Potential benefit: If successful, the findings could clarify which perineural injectate provides better symptom relief and potentially offer a simple, low‑risk option to reduce pain and improve mobility in knee osteoarthritis.
How similar studies have gone: Small observational and pilot studies of perineural dextrose have reported pain and function improvements and local anesthetics are known for short‑term relief, but large randomized head‑to‑head trials are lacking.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Symptomatic knee osteoarthritis * Clinical/radiological diagnosis * Knee pain ≥ 3 months * Written informed consent Exclusion Criteria: * Prior knee surgery * Recent intra-articular injection * Inflammatory rheumatic disease * Severe systemic or neurological disease * Pregnancy or breastfeeding
Where it's running
-
Ankara Training and Research Hospital Ankara, Altindag, Turkey, 06230
Ankara, Altindag, Turkey (Türkiye) Recruiting -
Ankara Training and Research Hospital Ankara, Altindag, Turkey, 06230
Ankara, Altindag, Turkey (Türkiye) Not yet recruiting
Study contacts
- Study coordinator: Nadide Koca, M.D.
- Email: nadide.koca@gmail.com
- Phone: +905376843434
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.