Perineural dextrose versus local anesthetic injections for knee osteoarthritis
A Prospective Evaluation of the Clinical Effectiveness of Perineural Dextrose and Conventional Local Anesthetic Injections in Patients With Symptomatic Knee Osteoarthritis
This study will test whether perineural 5% dextrose or perineural local anesthetic injections better reduce pain and improve function in adults aged 40–65 with symptomatic knee osteoarthritis.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 86 (estimated) |
| Ages | 40 Years to 65 Years |
| Sex | All |
| Sponsor | Ankara Training and Research Hospital Academic / other |
| Locations | 2 sites (Ankara, Altindag and 1 other locations) |
| Trial ID | NCT07381621 on ClinicalTrials.gov |
What this trial studies
This is a prospective observational cohort in a routine clinical setting comparing patients who receive perineural 5% dextrose injections or perineural local anesthetic injections as part of usual care. Treatment choice is determined by clinician judgment and patient preference rather than randomization. Participants will be followed for six months with outcome measures at baseline and at 1, 3, and 6 months. Outcomes include pain measured by VAS, function by WOMAC, knee range of motion by goniometry, and quadriceps strength.
Who should consider this trial
Good fit: Adults 40 to 65 years old with a clinical or radiological diagnosis of symptomatic knee osteoarthritis of at least three months' duration who can provide informed consent and attend follow-up visits.
Not a fit: Patients with prior knee surgery, recent intra‑articular injections, inflammatory rheumatic disease, severe systemic or neurological disease, or who are pregnant or breastfeeding are excluded and unlikely to benefit from these perineural injections.
Why it matters
Potential benefit: If successful, the findings could clarify which perineural injectate provides better symptom relief and potentially offer a simple, low‑risk option to reduce pain and improve mobility in knee osteoarthritis.
How similar studies have performed: Small observational and pilot studies of perineural dextrose have reported pain and function improvements and local anesthetics are known for short‑term relief, but large randomized head‑to‑head trials are lacking.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Symptomatic knee osteoarthritis * Clinical/radiological diagnosis * Knee pain ≥ 3 months * Written informed consent Exclusion Criteria: * Prior knee surgery * Recent intra-articular injection * Inflammatory rheumatic disease * Severe systemic or neurological disease * Pregnancy or breastfeeding
Where this trial is running
Ankara, Altindag and 1 other locations
- Ankara Training and Research Hospital Ankara, Altindag, Turkey, 06230 — Ankara, Altindag, Turkey (Türkiye) (Not_yet_recruiting)
- Ankara Training and Research Hospital Ankara, Altindag, Turkey, 06230 — Ankara, Altindag, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Nadide Koca, M.D.
- Email: nadide.koca@gmail.com
- Phone: +905376843434
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.