Peptide face cream compared side-by-side for skin hydration and barrier
Evaluation of the Effect of a Topical Formulation Containing Acetyl Hexapeptide-37 on Objective Skin Barrier Parameters of the Face in a Randomized Controlled Split-Face Design
This will test whether a face cream with Acetyl Hexapeptide-37 improves skin hydration and reduces water loss on one side of the face compared with a placebo in healthy adults.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | University of Split, School of Medicine Academic / other |
| Locations | 1 site (Split) |
| Trial ID | NCT07548424 on ClinicalTrials.gov |
What this trial studies
The trial uses a split-face design in healthy adult volunteers to compare a topical cream containing Acetyl Hexapeptide-37 against a placebo cream applied to the opposite side of the face. Baseline and follow-up measurements include skin hydration, transepidermal water loss (TEWL), and erythema to detect changes in barrier function and irritation. Participants also provide ratings of comfort and tolerability while using the products. Outcomes compare the treated and placebo sides to determine any differences in skin barrier metrics or adverse effects.
Who should consider this trial
Good fit: Healthy adults without active facial skin disease who are not pregnant or breastfeeding and are not using topical or systemic corticosteroids or immunosuppressive drugs are ideal candidates.
Not a fit: People with active dermatologic conditions, known allergy to any product ingredient, pregnant or breastfeeding individuals, or those on corticosteroids/immunosuppressants are unlikely to benefit or are excluded.
Why it matters
Potential benefit: If effective, the peptide cream could provide a simple topical method to increase facial skin hydration and strengthen the skin barrier with minimal systemic risk.
How similar studies have performed: Prior small cosmetic studies of topical peptides have shown mixed effects on skin appearance, but direct evidence that Acetyl Hexapeptide-37 improves hydration or barrier function is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * healthy volunteers who gave written informed consent Exclusion Criteria: * presence of active skin diseases or dermatological conditions * known allergy or hypersensitivity to any ingredient of the study products * pregnancy or breastfeeding * use of topical or systemic corticosteroids, immunosuppressive drugs, or antihistamines prior to or during the study
Where this trial is running
Split
- University of Split School of Medicine — Split, Croatia (Recruiting)
Study contacts
- Study coordinator: Josipa Bukić, MPharm
- Email: jbukic@mefst.hr
- Phone: +385917933753
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.