Pentoxifylline plus CoQ10 versus CoQ10 alone to improve sperm motility in men with asthenozoospermia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, controlled trial enrolling 56 subfertile men with asthenozoospermia at Bangladesh Medical University. Participants are randomly assigned to receive pentoxifylline 400 mg twice daily plus CoQ10 100 mg twice daily, or CoQ10 100 mg twice daily alone, for three months. Baseline semen analysis requires two samples and the main outcome is change in sperm motility after three months, with monitoring for adverse events. Allocation is concealed using serially numbered opaque envelopes and safety and demographic data are collected throughout.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Sub fertile men with asthenozoospermia(Total motility20% to less than 42%) according to WHO semen analysis,2021.
* Age 20-50 years.

Exclusion Criteria:

* Severe oligoasthenoteratozoospermia
* Any medical, endocrine and genetic disorders, history of chemotherapy or radiotherapy, genital infection, genital surgery.
* Antioxidants supplmentation in the last 3 months
* Drug, alcohol or substance abuse, psycho-sexual abnormalities.
* Any known hypersensitivity to xanthine related product, recent cerebral or retinal haemorrhage Severe oligoasthenoteratozoospermia
* Any medical, endocrine and genetic disorders, history of chemotherapy or radiotherapy, genital infection, genital surgery.
* Antioxidants supplmentation in the last 3 months
* Drug, alcohol or substance abuse, psycho-sexual abnormalities.
* Any known hypersensitivity to xanthine related product, recent cerebral or retinal haemorrhage

Where it's running

• Bangladesh Medical University
  Dhaka, Shahbag, Bangladesh Recruiting

Study contacts

• Principal investigator: Jesmine Banu, MS — Bangladesh Medical University
• Study coordinator: Mst.Sumyara Khatun, MS
• Email: sumirmc09@gmail.com
• Phone: +8801746046581

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.