Peer support for mental health in people with substance use disorders

Peer to Peer (P2P): Mental Health Interventions with Persons with Substance Use Disorders

NA · Prisma Health-Upstate · NCT06803810

This study is testing whether peer support and therapy can help people with substance use disorders improve their mental health and recovery, especially in rural areas.

Quick facts

PhaseNA
Study typeInterventional
Enrollment100 (estimated)
Ages18 Years and up
SexAll
SponsorPrisma Health-Upstate (other)
Locations1 site (Greenville, South Carolina)
Trial IDNCT06803810 on ClinicalTrials.gov

What this trial studies

This project offers peer support services to individuals with substance use disorders, focusing on mental health challenges such as anxiety and depression that hinder recovery. Participants will receive assessments for opioid use disorder and social determinants of health, followed by six weekly problem-solving therapy sessions led by a certified peer support specialist. The intervention aims to connect patients with sustainable mental health resources and provide ongoing support for up to 12 weeks. The approach is designed to address behavioral health disparities in rural areas.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 and older diagnosed with opioid use disorder and experiencing moderate to severe depression.

Not a fit: Patients with severe cognitive, medical, or psychiatric disabilities, or those currently experiencing suicidal ideation, may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly improve mental health outcomes and recovery rates for individuals with substance use disorders.

How similar studies have performed: Other studies have shown promise in using peer support interventions for mental health and substance use disorders, indicating a potential for success in this approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosis of OUD via Diagnostic Statistical Manual (DSM)-V Text Revision (TR)
* Receiving MOUD through the Mobile Recovery Program for at least 3 months
* Age 18 or older
* Moderate to Severe Depression with or without co-occurring anxiety as determined by PHQ-9 conducted during the most recent MRP clinical visit

Exclusion Criteria:

* Severe cognitive, medical, or psychiatric disability that could impair ability to perform study-related activities as determined by the MRP clinician or principal investigator.
* Unable to read/speak English
* Unable to read and comprehend the consent materials and other study materials
* Current suicidal ideation based on the Patient Health Questionnaire-9

Where this trial is running

Greenville, South Carolina

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Standard of Care, P2P Intervention

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.