Pediatric Critical Asthma: Dexamethasone vs Methylprednisolone in the PICU

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, phase 2 randomized trial enrolling children aged 3–17 years admitted to the ICU for critical asthma. Participants are randomized to one of three systemic corticosteroid regimens: dexamethasone 0.6 mg/kg once daily (max 16 mg) for 2 days, dexamethasone 0.25 mg/kg every 6 hours for 2 days, or methylprednisolone 1 mg/kg every 6 hours for 5 days. The study aims to compare subsequent need for additional corticosteroids and to explore quality-of-life outcomes as secondary endpoints. The trial builds on prior work suggesting variability in corticosteroid choice and schedules may influence resource use and patient experience during pediatric critical asthma episodes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 3-17 years
* Intensive care unit admission
* Treatment for critical asthma

Exclusion Criteria:

* History of unrepaired critical congenital heart disease
* History of cystic fibrosis
* Active tracheostomy dependence

Where it's running

• Johns Hopkins All Children's Hospital
  St. Petersburg, Florida, United States Recruiting

Study contacts

• Principal investigator: Meghan Sorondo, PharmD — Johns Hopkins All Children's Hospital
• Study coordinator: Meghan Sorondo, PharmD
• Email: mroddy4@jhmi.edu
• Phone: 727-767-7044

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• IOS-based platform to screen, diagnose, and manage COPD and asthma

  This study tests an Impulse Oscillometry system to screen for and diagnose COPD and asthma and to help predict flare-ups over about a year, involving adults in China.

  Recruiting Beijing Chao Yang Hospital · Beijing, Beijing Municipality · NCT07910409

• REACH: Resources and Education to Help Kids with Asthma in School

  A service model called REACH will try to improve school-based asthma care by coordinating care between healthcare, school, and home for children with asthma.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT07819747

• Beclometasone Dipropionate and Formoterol inhalation combo vs FOSTER in adults with asthma

  This Phase 3 trial tests whether a beclometasone formoterol inhalation combo works as well or better than FOSTER for adults with asthma.

  Recruiting Phase 3 Lunan Better Pharmaceutical Co., LTD. · Shanghai, Shanghai Municipality · NCT07768891

• Test of SKB575 in adults with asthma

  This study tests whether SKB575 helps people with asthma compared to a placebo.

  Recruiting at 2 sites Phase 1 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. · Chengdu, Sichuan and 1 other locations · NCT07732023

• KT-621 long-term safety and efficacy in asthma patients previously in KT-621 study

  This phase 2b study tests KT-621 in people with asthma who finished a prior KT-621 study to see if long-term treatment is safe and helpful.

  Recruiting at 7 sites Phase 2 Kymera Therapeutics, Inc. · Miami, Florida and 6 other locations · NCT07677059

• Dog-allergy immunotherapy with Alutard SQ Dog in Swedish practice

  This study tests whether Alutard SQ Dog immunotherapy helps adults with moderate-to-severe dog allergy when used in real-world Swedish care.

  Recruiting at 2 sites Phase 4 Karolinska Institutet · Lund, Skåne County and 1 other locations · NCT07651891

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.