Passive robots and electrical stimulation to help arm recovery after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Many stroke survivors have lasting upper‑extremity weaknesses but high‑end robotic rehab is often too expensive or bulky for routine or home use. This study uses a table‑top semi‑passive device called SepaRRo together with a custom controller that triggers neuromuscular electrical stimulation (NeuRRoFES) during functional tasks. Participants will undergo long‑term training with these tools while researchers measure technical feasibility (adherence, time on task, retention, ability to perform tasks, and user feedback) and clinical signals of change (biomechanical, neurophysiological, and functional measures). The goal is to determine whether this affordable, compliant system could be practical for wider clinical or home rehabilitation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 to 75 years;
* Ischemic or hemorrhagic stroke confirmed by CT, MRI, or clinical criteria;
* No major deficits of sensation or proprioception;

Exclusion Criteria:

* Bilateral stroke
* Unable to think clearly and remember (Mini-Mental State Exam score \< 22 and miniMOCA \< 8);
* Uncontrolled Diabetes or Hypertension;
* Severe limitations of joint range of motion that will lead to inability of testing
* Severe spasticity and joint contractures that will lead to inability of testing
* Complete paresis with no possible movements
* Severe aphasia
* Any other medical condition that will significantly impact the study results
* Unable to obtain reliable motor evoked potentials
* Are pregnant or are actively trying to conceive
* Have a recent history of repeated fainting spells or syncope.
* Have a recent history of seizure (epilepsy) while on anti-seizure medication
* Have a recent history of skull fracture/head injury
* Have metal implants in the skull
* Have cardiac pacemakers

Where it's running

• University of Michigan - NeuRRo Lab
  Ann Arbor, Michigan, United States Recruiting

Study contacts

• Principal investigator: Chandramouli Krishnan, PT, PhD — University of Michigan
• Study coordinator: Chandramouli Krishnan, PT, PhD
• Email: mouli@umich.edu
• Phone: 7349364031

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Web-based therapy using action observation and mirror therapy for arm weakness after stroke

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• Remote Ischaemic Conditioning for Fatigue After Stroke 2

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• Dual-task balance training plus computer-based cognitive training after stroke

  In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.

  Recruiting Matia Foundation · San Sebastián, GUIPUZCOA · NCT07913620

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.