Parvovirus B19 in pregnancy and its effects on the baby
Parvovirus B19 Infection in Pregnancy: Clinical Manifestations and Fetus/Newborn Outcome
This project follows pregnant women who get parvovirus B19 and their babies to see how often the infection causes problems for the fetus or newborn.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia Academic / other |
| Locations | 5 sites (Pavia, Lombardy and 4 other locations) |
| Trial ID | NCT07338279 on ClinicalTrials.gov |
What this trial studies
Researchers will collect clinical data from pregnant women over 18 with confirmed parvovirus B19 infection and from their neonates to determine the rate of intrauterine transmission and fetal/newborn complications. The study will record maternal risk factors, pregnancy outcomes, management interventions, and longer-term sequelae in infants. Data will be gathered at participating hospitals in Lombardy, Italy, and analyzed to identify factors associated with worse outcomes and to evaluate the effectiveness of current management approaches. As an observational registry, no experimental treatments are assigned.
Who should consider this trial
Good fit: Ideal candidates are pregnant women older than 18 years with confirmed parvovirus B19 infection and their newborns.
Not a fit: People without parvovirus B19 infection, those under 18, or those unable to attend follow-up at the participating hospitals are unlikely to benefit from this project.
Why it matters
Potential benefit: If successful, the findings could help clinicians better predict fetal risk, refine management strategies in pregnancy, and provide clearer counseling for affected families.
How similar studies have performed: Previous observational work has documented risks such as fetal hydrops and pregnancy loss after maternal parvovirus B19 infection, so this study builds on existing clinical knowledge rather than testing a novel therapy.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pregnant women \>18 years with parvovirus B19 infection and their neonates. Exclusion Criteria: * None
Where this trial is running
Pavia, Lombardy and 4 other locations
- Fondazione IRCCS Policlinico San Matteo — Pavia, Lombardy, Italy (Recruiting)
- ASST degli Spedali Civili di Brescia — Brescia, Italy (Not_yet_recruiting)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico — Milan, Italy (Recruiting)
- ASST Fatebenefratelli Sacco — Milan, Italy (Recruiting)
- Fondazione IRCCS San Gerardo dei Tintori — Monza, Italy (Not_yet_recruiting)
Study contacts
- Study coordinator: Daniele Lilleri
- Email: d.lilleri@smatteo.pv.it
- Phone: +39 0382 502420
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.