Parathyroid removal to improve mobility in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational study enrolling up to 80 adults aged 60 and older who are undergoing parathyroidectomy at UF Health. Participants will complete standardized physical performance tests, wear an Actigraph device to measure real-world physical activity, and provide blood samples for inflammatory and other biomarker analysis at pre- and post-operative time points. The study will characterize changes in physical function and activity after surgery and look for biomarkers that predict who improves. Results are intended to inform larger trials and could influence surgical decision-making for older adults with primary hyperparathyroidism.

Why it matters

Who can join: the full rules

Inclusion:

* Age ≥ 60 years;
* Biochemical diagnosis of hypercalcemic (corrected serum calcium \>10.2 mg/dL or ionized serum calcium \>1.31 mmol/dL or 5.2 mg/dL on at least one serum sample) primary hyperparathyroidism as determined by board-certified endocrinologist or endocrine surgeon;
* Undergoing parathyroidectomy at UF Health;
* Willing and able to give informed consent.

Exclusion:

* Failure to provide informed consent;
* Biochemical diagnosis of eucalcemic primary hyperparathyroidism (corrected serum calcium ≤10.2 mg/dL or ionized serum calcium ≤1.31 mmol/dL or 5.2 mg/dL on at least one serum sample);
* Elected not to undergo parathyroidectomy at UF Health;
* Major surgery as deemed by principal investigator or hip/knee replacement in the past 6 months;
* Fractures to the hands, arms or legs within the last 6 months;
* Traumatic accident (i.e. motor vehicle collision, fall from elevation, etc.) resulting in orthopedic trauma or requiring prolonged immobilization (\>2 weeks) within the last 6 months;
* Blood transfusion within the past 3 months;
* Self-reported myocardial infarction, cerebrovascular accident, or unstable angina within the past 6 months;
* NYHA Class 3 or 4 congestive heart failure;
* Major psychiatric disorder;
* Cancer requiring treatment in the past 1 year (including metastatic cancer), except for locally treated non-melanoma skin cancers or cancers that have clearly been cured or in the opinion of the investigator carry an excellent prognosis (e.g., Stage 1 cervical cancer);
* Renal failure requiring hemodialysis or peritoneal dialysis
* Use of bone-modifying therapies (alendronate \[Fosamax\], zoledronic acid \[Reclast\], denosumab \[Prolia or Xgeva\], or romosozumab \[Evenity\]) within 1 month of planned surgery
* Planning to permanently leave the area within 3 months of parathyroidectomy;
* Vision or hearing impairment - defined as unable to read or listen/follow instructions despite the use of maximal assistive devices (i.e. contact lenses, glasses, hearing aids, etc.)
* Participating in another clinical trial or has received an investigational product within 30 days prior to screening/enrollment.

Where it's running

• Clinical and Translational Research Building
  Gainesville, Florida, United States Recruiting

Study contacts

• Study coordinator: Rezvan Ghaderpanah, MD
• Email: ghaderpanah.r@ufl.edu
• Phone: 352-273-5919

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Flurpiridaz F-18 PET/CT to Find Parathyroid Adenomas

  This study tests whether Flurpiridaz F-18 PET/CT can better detect abnormal parathyroid glands in adults with primary hyperparathyroidism before surgery.

  Recruiting Early Phase 1 University of Pennsylvania · Philadelphia, Pennsylvania · NCT07910097

• Spinal Mobility, Rigidity, and Kinesiophobia in Parkinson's Disease with and without TMD

  This study tests whether people with Parkinson's disease who have Temporomandibular Disorders differ in spinal mobility, axial rigidity, and kinesiophobia from those without TMD.

  Recruiting Mustafa Kemal University · Hatay · NCT07850674

• Stretching plus kinesiotape for pregnancy-related low back pain

  This trial tests whether adding kinesiotaping to prenatal stretching helps pregnant women (ages 18–35, 20–34 weeks) reduce low back pain and improve mobility and quality of life.

  Recruiting Riphah International University · Rahim Yar Khan, Punjab Province · NCT07579039

• Using PTeye to help protect parathyroid glands during total thyroidectomy

  This trial will test whether using the handheld PTeye device during total thyroidectomy in adults reduces the chance of low blood calcium after surgery.

  Recruiting The University of Hong Kong · Hong Kong · NCT07416149

• Parathyroid surgery for persistent overactive parathyroid glands after kidney transplant.

  This will test whether removing part of the parathyroid glands helps kidney transplant recipients who still have high parathyroid hormone and abnormal calcium or phosphate levels.

  Recruiting University of Aarhus · Aarhus, Central Jutland · NCT07415421

• Validating lab assays, IV catheter techniques, and devices for endocrine, cardiometabolic, and musculoskeletal conditions

  This project will test whether laboratory assays, IV catheter methods, and equipment give consistent, reliable results in adults with or without obesity-related, metabolic, or musculoskeletal conditions.

  Recruiting University of Missouri-Columbia · Columbia, Missouri · NCT07083557

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.