Parametric PET imaging for infections on prosthetic heart valves
Official title: Interest of Parametric Positron Emission Computed Tomography Imaging in the Diagnosis of Infections on Cardiac Valve Prosthesis : PARAVA Study
Run by Centre Henri Becquerel · NCT05146180 · Data updated 2026-11-12
This study will test whether an advanced parametric PET scan helps diagnose infections in people with prosthetic heart valves.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Centre Henri Becquerel Academic / other |
| Locations | 1 site (Rouen) |
| Status | Recruiting |
| Started | February 24, 2022 |
| Main results expected | December 1, 2026 |
| Study ends | March 1, 2027 |
| Registry record updated | January 2, 2026 |
| Trial ID | NCT05146180 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (age >18) with suspected endocarditis on a prosthetic heart valve implanted more than three months earlier who can undergo FDG-PET/CT and provide informed consent.
✕Probably not a fit
People who are pregnant or breastfeeding, have had active cancer in the past three years, have poorly controlled diabetes, cannot lie flat for the scan, or are under legal protection are excluded and would not directly benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with suspected prosthetic valve endocarditis will receive the usual diagnostic work-up (blood tests, echocardiography, labeled leukocyte scintigraphy) plus an added parametric FDG-PET/CT acquisition performed during their planned PET/CT. The parametric acquisition data are collected in addition to standard PET images and analyzed separately. A definitive diagnosis using the modified Duke-Li criteria will be established at a multidisciplinary meeting three months later, with reviewers blinded to the parametric PET results but aware of standard PET and other work-up. The study compares parametric PET findings to the final clinical diagnosis to see if the parametric approach improves early detection of prosthetic valve infections.
Why it matters
Potential benefit: If successful, this technique could enable earlier and more accurate diagnosis of prosthetic valve infections, allowing faster, targeted treatment.
How similar studies have gone: Standard FDG-PET/CT has demonstrated usefulness for prosthetic valve endocarditis, but parametric PET acquisition is a newer technique with limited prior clinical data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age superior to18 years, * Effective contraception for women of childbearing age or negative pregnancy test on the day of the exam * Good general condition. WHO ≤ 1 * Suspicion of endocarditis on a prosthetic heart valve implanted more than 3 months ago * Labeled polynuclear scintigraphy performed within a maximum of 15 days before positron emission computed tomography * Standard positron emission computed tomography planned as part of the extension assessment * Informed and signed consent before any specific study procedure. * Patient affiliated to the social security system Exclusion Criteria: * Presence of an active cancer in the previous three years * Pregnancy or breastfeeding * Poorly controlled diabetic patients * Protected adults (under guardians or curators) * Impossible decubitus (orthopnea, ...), * Hypersensitivity to FDG or to one of the excipients of the radiopharmaceutical.
Where it's running
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Centre Henri Becquerel
Rouen, France Recruiting
Study contacts
- Principal investigator: Mathieu Chastan, MD — Centre Henri Becquerel
- Study coordinator: Mathieu Chastan, MD
- Email: mathieu.chastan@chb.unicancer.fr
- Phone: +33276673032
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Barts Endocarditis Registry
This registry collects health, imaging, microbiology, treatment, and outcome information from adults with infective endocarditis seen at Barts Heart Centre to learn which approaches work best.
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Evaluating the effect of dental screenings on infective endocarditis risk in heart valve surgery patients
This study is testing whether changing dental screening procedures can lower the risk of infective endocarditis in patients having heart valve surgery.
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Evaluating the effect of dental screenings on endocarditis risk in TAVI patients
This study looks at whether changing dental check-up rules can lower the risk of heart infections in patients getting a new heart valve through a procedure called TAVI.
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Comparing patients with and without endocarditis undergoing valve surgery
This study looks at how patients with and without endocarditis do during heart valve surgery to see if their treatment and recovery needs are different.
-
Cytokine removal in critically ill patients with infective endocarditis
This study is testing if a treatment that removes certain immune proteins can help critically ill patients with infective endocarditis recover better after heart surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.