Paired intracoronary OCT and coronary CT angiography to map plaque and blockages
Official title: Bern Intarcoronary Optical Coherence Tomography and Coronary Computed Tomography Angiography Registry
Run by Insel Gruppe AG, University Hospital Bern · NCT07565805 · Data updated 2026-11-12
This project will test whether advanced coronary CT scans can provide the same detailed plaque and blockage information as invasive intracoronary optical coherence tomography (OCT) in adults with coronary artery disease who have both scans.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 816 (estimated) |
| Sponsor | Insel Gruppe AG, University Hospital Bern Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Bern) |
| Status | Recruiting |
| Started | October 17, 2025 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2033 |
| Registry record updated | May 12, 2026 |
| Trial ID | NCT07565805 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) who give written consent, have a CCTA within three months of invasive coronary angiography and OCT, have at least one vessel with ≥50% stenosis on CCTA, and have OCT performed in native coronary arteries (pre-PCI or no PCI).
✕Probably not a fit
Patients with prior PCI or CABG in the vessel imaged, coronary anomalies, or poor-quality OCT or CCTA images are unlikely to receive useful matched imaging information from this registry.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
BIOCORE is a systematic registry at Bern University Hospital enrolling adults with coronary artery disease who undergo both coronary computed tomography angiography (CCTA) and intracoronary optical coherence tomography (OCT). The registry requires CCTA within three months of invasive coronary angiography and OCT, and at least one vessel with ≥50% diameter stenosis on CCTA, with OCT performed in native arteries before any PCI. The project compares advanced CCTA techniques (including photon-counting CT and AI-driven analyses) against OCT as the invasive gold standard for plaque morphology, lesion severity, and PCI guidance. Imaging features will be linked to long-term clinical outcomes to improve noninvasive diagnosis and treatment planning.
Why it matters
Potential benefit: If successful, this work could allow noninvasive CCTA (with newer hardware and AI tools) to reliably characterize plaque and help guide treatment decisions that today often require invasive imaging.
How similar studies have gone: While improvements in CCTA technology and AI analyses are promising, direct paired comparisons with OCT are limited, so this paired-registry approach is relatively novel though grounded in existing imaging research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. ≥18 years of age 2. Written informed consent 3. CCTA within 3 months from invasive coronary angiography and OCT 4. At least one vessel with ≥50% diameter stenosis on CCTA 5. OCT performed in native coronary arteries (i.e. pre-PCI or no PCI) Exclusion Criteria: 1. CCTA performed more than 3 months from OCT 2. Poor OCT quality 3. Poor CCTA quality 4. Coronary anomalies 5. Prior PCI or CABG in the vessel imaged with OCT
Where it's running
-
Department of Cardiology, Bern University Hospital Inselspital
Bern, Switzerland Recruiting
Study contacts
- Principal investigator: Sarah Bär, MD-PhD — Department of Cardiology, Bern University Hospital Inselspital, Switzerland
- Study coordinator: Sarah Bär, MD, PhD
- Email: sarah.baer@insel.ch
- Phone: +41316322111
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.